| Literature DB >> 33551837 |
Kıvılcım Kılıç1, Michèle Desjardins2, Jianbo Tang1,3, Martin Thunemann1, Smrithi Sunil1, Şefik Evren Erdener1,4, Dmitry D Postnov1,5, David A Boas1, Anna Devor1.
Abstract
Chronic cranial windows allow for longitudinal brain imaging experiments in awake, behaving mice. Different imaging technologies have their unique advantages and combining multiple imaging modalities offers measurements of a wide spectrum of neuronal, glial, vascular, and metabolic parameters needed for comprehensive investigation of physiological and pathophysiological mechanisms. Here, we detail a suite of surgical techniques for installation of different cranial windows targeted for specific imaging technologies and their combination. Following these techniques and practices will yield higher experimental success and reproducibility of results.Entities:
Keywords: awake; chronic; imaging; mice; multimodal; neural; vascular
Year: 2021 PMID: 33551837 PMCID: PMC7862556 DOI: 10.3389/fphys.2020.612678
Source DB: PubMed Journal: Front Physiol ISSN: 1664-042X Impact factor: 4.566