Yuhua Chen1,2,3, Yan Li4, Limin Guo2, Jun Hong2, Wenjuan Zhao2, Ximin Hu5, Cuicui Chang1, Wei Liu3, Kun Xiong2,6. 1. Central Laboratory of Medicine School, Xi'an Peihua University, Xi'an, China. 2. Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China. 3. Department of Neurosurgery, First Affiliated Hospital of Xiamen University, Xiamen, China. 4. Department of Histology and Embryology, School of Basic Medical Science, Xinjiang Medical University, Urumqi, China. 5. Clinical Medicine Eight-year Program, 02 Class, 17 Grade, Xiangya School of Medicine, Central South University, Changsha, China. 6. Hunan Key Laboratory of Ophthalmology, Changsha, China.
Abstract
Background: Considering the pivotal role of inflammasome/pyroptosis in biological function, we visually analyzed the research hotspots of inflammasome/pyroptosis related to the brain in this work through the method of bibliometrics from the Web of Science (WOS) Core database over the past two decades. Methods: Documents were retrieved from WOS Core Collection on October 16, 2020. The search terms and strategies used for the WOS database are as follow: # 1, "pyroptosis"; # 2, "pyroptotic"; # 3, "inflammasome"; # 4, "pyroptosome"; # 5 "brain"; # 6, "# 1" OR "# 2" OR "# 3" OR "# 4"; # 7, "# 5" AND "# 6". We selected articles and reviews published in English from 2000 to 2020. Visualization analysis and statistical analysis were performed by VOSviewer 1.6.15 and CiteSpace 5.7. R2. Results: 1,222 documents were selected for analysis. In the approximately 20 years since the pyroptosis was first presented, the publications regarding the inflammasome and pyroptosis in brain were presented since 2005. The number of annual publications increased gradually over a decade, which are involved in this work, and will continue to increase in 2020. The most prolific country was China with 523 documents but the United States was with 16,328 citations. The most influential author was Juan Pablo de Rivero Vaccari with 27 documents who worked at the University of Miami. The bibliometric analysis showed that inflammasome/pyroptosis involved a variety of brain cell types (microglia, astrocyte, neuron, etc.), physiological processes, ER stress, mitochondrial function, oxidative stress, and disease (traumatic brain injuries, stroke, Alzheimer's disease, and Parkinson's disease). Conclusion: The research of inflammasome/pyroptosis in brain will continue to be the hotspot. We recommend investigating the mechanism of mitochondrial molecules involved in the complex crosstalk of pyroptosis and regulated cell deaths (RCDs) in brain glial cells, which will facilitate the development of effective therapeutic strategies targeting inflammasome/pyroptosis and large-scale clinical trials. Thus, this study presents the trend and characteristic of inflammasome/pyroptosis in brain, which provided a helpful bibliometric analysis for researchers to further studies.
Background: Considering the pivotal role of inflammasome/pyroptosis in biological function, we visually analyzed the research hotspots of inflammasome/pyroptosis related to the brain in this work through the method of bibliometrics from the Web of Science (WOS) Core database over the past two decades. Methods: Documents were retrieved from WOS Core Collection on October 16, 2020. The search terms and strategies used for the WOS database are as follow: # 1, "pyroptosis"; # 2, "pyroptotic"; # 3, "inflammasome"; # 4, "pyroptosome"; # 5 "brain"; # 6, "# 1" OR "# 2" OR "# 3" OR "# 4"; # 7, "# 5" AND "# 6". We selected articles and reviews published in English from 2000 to 2020. Visualization analysis and statistical analysis were performed by VOSviewer 1.6.15 and CiteSpace 5.7. R2. Results: 1,222 documents were selected for analysis. In the approximately 20 years since the pyroptosis was first presented, the publications regarding the inflammasome and pyroptosis in brain were presented since 2005. The number of annual publications increased gradually over a decade, which are involved in this work, and will continue to increase in 2020. The most prolific country was China with 523 documents but the United States was with 16,328 citations. The most influential author was Juan Pablo de Rivero Vaccari with 27 documents who worked at the University of Miami. The bibliometric analysis showed that inflammasome/pyroptosis involved a variety of brain cell types (microglia, astrocyte, neuron, etc.), physiological processes, ER stress, mitochondrial function, oxidative stress, and disease (traumatic brain injuries, stroke, Alzheimer's disease, and Parkinson's disease). Conclusion: The research of inflammasome/pyroptosis in brain will continue to be the hotspot. We recommend investigating the mechanism of mitochondrial molecules involved in the complex crosstalk of pyroptosis and regulated cell deaths (RCDs) in brain glial cells, which will facilitate the development of effective therapeutic strategies targeting inflammasome/pyroptosis and large-scale clinical trials. Thus, this study presents the trend and characteristic of inflammasome/pyroptosis in brain, which provided a helpful bibliometric analysis for researchers to further studies.
Authors: Juan Pablo de Rivero Vaccari; George Lotocki; Ofelia F Alonso; Helen M Bramlett; W Dalton Dietrich; Robert W Keane Journal: J Cereb Blood Flow Metab Date: 2009-04-29 Impact factor: 6.200
Authors: Christina Ising; Carmen Venegas; Shuangshuang Zhang; Hannah Scheiblich; Susanne V Schmidt; Ana Vieira-Saecker; Stephanie Schwartz; Shadi Albasset; Róisín M McManus; Dario Tejera; Angelika Griep; Francesco Santarelli; Frederic Brosseron; Sabine Opitz; James Stunden; Maximilian Merten; Rakez Kayed; Douglas T Golenbock; David Blum; Eicke Latz; Luc Buée; Michael T Heneka Journal: Nature Date: 2019-11-20 Impact factor: 49.962