Baoxia Gu1, Xiaogai Shang2, Mengqing Yan3, Xiao Li3, Wei Wang3, Qi Wang4, Cuilian Zhang5. 1. Reproductive Medicine Center, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Henan Joint International Research Laboratory of Reproductive Bioengineering, No.7, Weiwu Rd, Zhengzhou City, Henan 450003, China; Reproductive Medical Center, Henan University People's Hospital, Henan Provincial People's Hospital, No.7, Weiwu Rd, Zhengzhou City, Henan 450003, China. 2. Reproductive Medical Center, Henan University People's Hospital, Henan Provincial People's Hospital, No.7, Weiwu Rd, Zhengzhou City, Henan 450003, China. 3. College of Public Health, Zhengzhou University, Zhengzhou City, Henan 450001, China. 4. College of Public Health, Zhengzhou University, Zhengzhou City, Henan 450001, China; China-Canada Medical and Healthcare Science Association, Toronto, ON L3R 1A3, Canada. Electronic address: qi.wang@ccmhsa.org. 5. Reproductive Medicine Center, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Henan Joint International Research Laboratory of Reproductive Bioengineering, No.7, Weiwu Rd, Zhengzhou City, Henan 450003, China; Reproductive Medical Center, Henan University People's Hospital, Henan Provincial People's Hospital, No.7, Weiwu Rd, Zhengzhou City, Henan 450003, China. Electronic address: luckyzcl@qq.com.
Abstract
BACKGROUND: Endometrial cancer (EC) is a commonly diagnosed cancer in women. A comprehensive knowledge of its epidemiological features is essential for understanding the disease burden and guiding prevention strategies. METHODS: We retrieved the incidence and mortality data of EC from the Global Burden of Disease database. Estimated average percentage change (EAPC) was used to quantify the trends of the age-standardized incidence and mortality rates (ASIR and ASMR, respectively) of EC from 1990 to 2019. RESULTS: Globally, the ASIR of EC significantly increased by 0.69% (95% confidence interval [CI] 0.57-0.81%) per year between 1990 and 2019. This increasing trend was also observed in 160 countries or territories, regardless of the sociodemographic status. The most pronounced increase was found in Italy (EAPC = 4.81, 95% CI, 4.10-5.53), followed by Saudi Arabia and Singapore. Between 1990 and 2019, the ASMR of EC decreased significantly worldwide (EAPC = -0.85, 95% CI, -0.93 to -0.76) but increased significantly in 91 countries or territories, with the highest increase in Lesotho (EAPC = 3.27, 95% CI, 2.81-3.74). The ASMR-ASIR ratio of EC was higher in developing countries than in developed countries. This ratio showed a decreasing trend at the national level over the past three decades. CONCLUSIONS: EC incidence has ubiquitously increased worldwide. EC mortality has decreased at the global level but increased in many countries. More efforts are required to alleviate the disease burden of EC.
BACKGROUND:Endometrial cancer (EC) is a commonly diagnosed cancer in women. A comprehensive knowledge of its epidemiological features is essential for understanding the disease burden and guiding prevention strategies. METHODS: We retrieved the incidence and mortality data of EC from the Global Burden of Disease database. Estimated average percentage change (EAPC) was used to quantify the trends of the age-standardized incidence and mortality rates (ASIR and ASMR, respectively) of EC from 1990 to 2019. RESULTS: Globally, the ASIR of EC significantly increased by 0.69% (95% confidence interval [CI] 0.57-0.81%) per year between 1990 and 2019. This increasing trend was also observed in 160 countries or territories, regardless of the sociodemographic status. The most pronounced increase was found in Italy (EAPC = 4.81, 95% CI, 4.10-5.53), followed by Saudi Arabia and Singapore. Between 1990 and 2019, the ASMR of EC decreased significantly worldwide (EAPC = -0.85, 95% CI, -0.93 to -0.76) but increased significantly in 91 countries or territories, with the highest increase in Lesotho (EAPC = 3.27, 95% CI, 2.81-3.74). The ASMR-ASIR ratio of EC was higher in developing countries than in developed countries. This ratio showed a decreasing trend at the national level over the past three decades. CONCLUSIONS: EC incidence has ubiquitously increased worldwide. EC mortality has decreased at the global level but increased in many countries. More efforts are required to alleviate the disease burden of EC.
Authors: Sarah J Kitson; Olivia Aurangzeb; Jawaria Parvaiz; Artitaya Lophatananon; Kenneth R Muir; Emma J Crosbie Journal: Cancer Prev Res (Phila) Date: 2022-09-01
Authors: HyunA Jo; Se Ik Kim; Wenyu Wang; Aeran Seol; Youngjin Han; Junhwan Kim; In Sil Park; Juwon Lee; Juhwan Yoo; Kyung-Do Han; Yong Sang Song Journal: Front Oncol Date: 2022-06-16 Impact factor: 5.738
Authors: Jacopo Troisi; Antonio Mollo; Martina Lombardi; Giovanni Scala; Sean M Richards; Steven J K Symes; Antonio Travaglino; Daniele Neola; Umberto de Laurentiis; Luigi Insabato; Attilio Di Spiezio Sardo; Antonio Raffone; Maurizio Guida Journal: Biomolecules Date: 2022-09-02