| Literature DB >> 33550892 |
Lívia Bitencourt Pascoal1,2, Patrícia Brito Rodrigues1, Lívia Moreira Genaro2, Arilson Bernardo Dos Santos Pereira Gomes1, Daniel Augusto Toledo-Teixeira3, Pierina Lorencini Parise3, Karina Bispo-Dos-Santos3, Camila Lopes Simeoni3, Paula Veri Guimarães2, Lucas Ildefonso Buscaratti4, João Gabriel De Angeli Elston4, Henrique Marques-Souza4, Daniel Martins-de-Souza5,6, Maria De Lourdes Setsuko Ayrizono2, Lício Augusto Velloso7,8, José Luiz Proenca-Modena3,5, Pedro Manoel Mendes Moraes-Vieira5,9, Marcelo Alves Silva Mori5,10, Alessandro Santos Farias5,11, Marco Aurélio Ramirez Vinolo1,5, Raquel Franco Leal2,8.
Abstract
Microbiota-derived molecules called short-chain fatty acids (SCFAs) play a key role in the maintenance of the intestinal barrier and regulation of immune response during infectious conditions. Recent reports indicate that SARS-CoV-2 infection changes microbiota and SCFAs production. However, the relevance of this effect is unknown. In this study, we used human intestinal biopsies and intestinal epithelial cells to investigate the impact of SCFAs in the infection by SARS-CoV-2. SCFAs did not change the entry or replication of SARS-CoV-2 in intestinal cells. These metabolites had no effect on intestinal cells' permeability and presented only minor effects on the production of anti-viral and inflammatory mediators. Together our findings indicate that the changes in microbiota composition of patients with COVID-19 and, particularly, of SCFAs do not interfere with the SARS-CoV-2 infection in the intestine.Entities:
Keywords: COVID-19; SARS-CoV-2; human colonic samples; microbiota; short-chain fatty acids
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Year: 2021 PMID： 33550892 PMCID： PMC7889267 DOI： 10.1080/19490976.2021.1874740
Source DB: PubMed Journal: Gut Microbes ISSN： 1949-0976