Jennifer A Brown1, Brooke S Jackson1, Courtney R Burton1, Jennifer E Hoy1, John A Sweeney2, Godfrey D Pearlson3,4, Matcheri S Keshavan5, Sarah S Keedy6, Elliot S Gershon6, Carol A Tamminga7, Brett A Clementz1, Jennifer E McDowell1. 1. Departments of Psychology and Neuroscience, University of Georgia, Athens, GA, USA. 2. Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH, USA. 3. Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA. 4. Institute of Living/Hartford Hospital, Hartford, CT, USA. 5. Department of Psychiatry, Beth Israel Deaconess Hospital, Harvard Medical School, Boston, MA, USA. 6. Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA. 7. Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, TX, USA.
Abstract
OBJECTIVES: Affective and psychotic features overlap considerably in bipolar I disorder, complicating efforts to determine its etiology and develop targeted treatments. In order to clarify whether mechanisms are similar or divergent for bipolar disorder with psychosis (BDP) and bipolar disorder with no psychosis (BDNP), neurobiological profiles for both the groups must first be established. This study examines white matter structure in the BDP and BDNP groups, in an effort to identify portions of white matter that may differ between the bipolar and healthy groups or between the bipolar subgroups themselves. METHODS: Diffusion-weighted imaging data were acquired from participants with BDP (n = 45), BDNP (n = 40), and healthy comparisons (HC) (n = 66). Fractional anisotropy (FA), radial diffusivity (RD), and spin distribution function (SDF) values indexing white matter diffusivity or spin density were calculated and compared between the groups. RESULTS: In comparisons between both the bipolar groups and HC, FA (FDR < 0.00001) and RD (FDR = 0.0037) differed minimally, in localized portions of the left cingulum and corpus callosum, while reductions in SDF (FDR = 0.0002) were more widespread. The bipolar subgroups did not differ from each other on FA, RD, or SDF metrics. CONCLUSIONS: Together, these results demonstrate a novel profile of white matter differences in bipolar disorder and suggest that this white matter pathology is associated with the affective disturbance common to those with bipolar disorder rather than the psychotic features unique to some. The white matter alterations identified in this study may provide substrates for future studies examining specific mechanisms that target affective domains of illness.
OBJECTIVES: Affective and psychotic features overlap considerably in bipolar I disorder, complicating efforts to determine its etiology and develop targeted treatments. In order to clarify whether mechanisms are similar or divergent for bipolar disorder with psychosis (BDP) and bipolar disorder with no psychosis (BDNP), neurobiological profiles for both the groups must first be established. This study examines white matter structure in the BDP and BDNP groups, in an effort to identify portions of white matter that may differ between the bipolar and healthy groups or between the bipolar subgroups themselves. METHODS: Diffusion-weighted imaging data were acquired from participants with BDP (n = 45), BDNP (n = 40), and healthy comparisons (HC) (n = 66). Fractional anisotropy (FA), radial diffusivity (RD), and spin distribution function (SDF) values indexing white matter diffusivity or spin density were calculated and compared between the groups. RESULTS: In comparisons between both the bipolar groups and HC, FA (FDR < 0.00001) and RD (FDR = 0.0037) differed minimally, in localized portions of the left cingulum and corpus callosum, while reductions in SDF (FDR = 0.0002) were more widespread. The bipolar subgroups did not differ from each other on FA, RD, or SDF metrics. CONCLUSIONS: Together, these results demonstrate a novel profile of white matter differences in bipolar disorder and suggest that this white matter pathology is associated with the affective disturbance common to those with bipolar disorder rather than the psychotic features unique to some. The white matter alterations identified in this study may provide substrates for future studies examining specific mechanisms that target affective domains of illness.
Authors: Rocío Pérez-Iglesias; Diana Tordesillas-Gutiérrez; Philip K McGuire; Gareth J Barker; Roberto Roiz-Santiañez; Ignacio Mata; Enrique Marco de Lucas; Jose Manuel Rodríguez-Sánchez; Rosa Ayesa-Arriola; Jose L Vazquez-Barquero; Benedicto Crespo-Facorro Journal: Am J Psychiatry Date: 2010-02-16 Impact factor: 18.112
Authors: Pawel Skudlarski; David J Schretlen; Gunvant K Thaker; Michael C Stevens; Matcheri S Keshavan; John A Sweeney; Carol A Tamminga; Brett A Clementz; Kasey O'Neil; Godfrey D Pearlson Journal: Am J Psychiatry Date: 2013-08 Impact factor: 18.112
Authors: Richard S E Keefe; Terry E Goldberg; Philip D Harvey; James M Gold; Margaret P Poe; Leigh Coughenour Journal: Schizophr Res Date: 2004-06-01 Impact factor: 4.939
Authors: Jordan P Hamm; Lauren E Ethridge; John R Shapiro; Godfrey D Pearlson; Carol A Tamminga; John A Sweeney; Matcheri S Keshavan; Gunvant K Thaker; Brett A Clementz Journal: Bipolar Disord Date: 2013-08-14 Impact factor: 6.744