Prasanna Kulkarni1, Poornima Devkumar1, Indranil Chattopadhyay2. 1. Institute of Ayurveda and Integrative Medicine (I-AIM), Bangalore, India. 2. Department of Life Sciences, Central University of Tamil Nadu, Thiruvarur, 610005, India. indranil_ch@yahoo.com.
Abstract
OBJECTIVE: Differential alterations in gut microbiota and chronic low-grade inflammation play a critical role in the development of Type 2 diabetes (T2D). Here we aimed to investigate if dysbiosis of inflammation and anti-inflammation-associated gut bacterial communities in fecal samples of individuals had any influence on T2D using a 16S rRNA gene of V3 region sequencing at Illumina MiSeq platform. RESULTS: Our findings showed that a higher abundance of inflammatory bacteria such as Lactobacillus ruminis, Ruminococcus gnavus, Bacteroides caccae, Butyricimonas, and Collinsella aerofaciens, and lower abundance of anti-inflammatory bacteria such as Faecalibacterium prausnitzii, and Butyrivibrio that likely play a role in the development of T2D. Our findings hint the potential of indigenous microbiota in developing diagnostic markers and therapeutic targets in T2D.
OBJECTIVE: Differential alterations in gut microbiota and chronic low-grade inflammation play a critical role in the development of Type 2 diabetes (T2D). Here we aimed to investigate if dysbiosis of inflammation and anti-inflammation-associated gut bacterial communities in fecal samples of individuals had any influence on T2D using a 16S rRNA gene of V3 region sequencing at Illumina MiSeq platform. RESULTS: Our findings showed that a higher abundance of inflammatory bacteria such as Lactobacillus ruminis, Ruminococcus gnavus, Bacteroides caccae, Butyricimonas, and Collinsella aerofaciens, and lower abundance of anti-inflammatory bacteria such as Faecalibacterium prausnitzii, and Butyrivibrio that likely play a role in the development of T2D. Our findings hint the potential of indigenous microbiota in developing diagnostic markers and therapeutic targets in T2D.
Entities:
Keywords:
Diagnostic marker; Gut microbiota; Inflammation; Type 2 diabetes
Authors: Nadja Larsen; Finn K Vogensen; Frans W J van den Berg; Dennis Sandris Nielsen; Anne Sofie Andreasen; Bente K Pedersen; Waleed Abu Al-Soud; Søren J Sørensen; Lars H Hansen; Mogens Jakobsen Journal: PLoS One Date: 2010-02-05 Impact factor: 3.240
Authors: Lukas Bajer; Miloslav Kverka; Martin Kostovcik; Peter Macinga; Jiri Dvorak; Zuzana Stehlikova; Jan Brezina; Pavel Wohl; Julius Spicak; Pavel Drastich Journal: World J Gastroenterol Date: 2017-07-07 Impact factor: 5.742
Authors: Tymofiy Lutsiv; Tiffany L Weir; John N McGinley; Elizabeth S Neil; Yuren Wei; Henry J Thompson Journal: Nutrients Date: 2021-11-09 Impact factor: 5.717