Maria A Lankinen1, Vanessa D de Mello1, Topi Meuronen1, Taisa Sallinen1, Jyrki Ågren2, Kirsi A Virtanen1,3, Markku Laakso4,5, Jussi Pihlajamäki1,3, Ursula Schwab1,3. 1. Institute of Public Health and Clinical Nutrition, School of Medicine, University of Eastern Finland, Kuopio, Finland. 2. Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland. 3. Department of Medicine, Endocrinology and Clinical Nutrition, Kuopio University Hospital, Kuopio, Finland. 4. Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland. 5. Department of Medicine, Kuopio University Hospital, Kuopio, Finland.
Abstract
SCOPE: The article investigates the FADS1 rs174550 genotype interaction with dietary intakes of high linoleic acid (LA) and high alpha-linolenic acid (ALA) on the response of fatty acid composition of plasma phospholipids (PLs), and of markers of low-grade inflammation and glucose-insulin homeostasis. METHODS AND RESULTS:One-hundred thirty homozygotes men for FADS1rs174550 SNP (TT and CC genotypes) were randomized to an 8-week intervention with either LA- or ALA-enriched diet (13 E% PUFA). The source of LA and ALA are 30-50 mL of sunflower oil (SFO, 62-63% LA) and Camelina sativa oil (CSO, 30- are randomized to an 35% ALA), respectively. In the SFO arm, there is a significant genotype x diet interaction for the proportion of arachidonic acid in plasma phospholipids (p < 0.001), disposition index (DI30 ) (p = 0.039), and for serum high-sensitive c-reactive protein (hs-CRP, p = 0.029) after excluding the participants with hs-CRP concentration of >10 mg L-1 and users of statins or anti-inflammatory therapy. In the CSO arm, there are significant genotype x diet interactions for n-3 polyunsaturated fatty acids, but not for the clinical characteristics. CONCLUSIONS: The FADS1 genotype modifies the response to high PUFA diets, especially to high-LA diet. These findings suggest that approaches considering FADS variation may be useful in personalized dietary counseling.
RCT Entities:
SCOPE: The article investigates the FADS1rs174550 genotype interaction with dietary intakes of high linoleic acid (LA) and high alpha-linolenic acid (ALA) on the response of fatty acid composition of plasma phospholipids (PLs), and of markers of low-grade inflammation and glucose-insulin homeostasis. METHODS AND RESULTS: One-hundred thirty homozygotes men for FADS1rs174550 SNP (TT and CC genotypes) were randomized to an 8-week intervention with either LA- or ALA-enriched diet (13 E% PUFA). The source of LA and ALA are 30-50 mL of sunflower oil (SFO, 62-63% LA) and Camelina sativa oil (CSO, 30- are randomized to an 35% ALA), respectively. In the SFO arm, there is a significant genotype x diet interaction for the proportion of arachidonic acid in plasma phospholipids (p < 0.001), disposition index (DI30 ) (p = 0.039), and for serum high-sensitive c-reactive protein (hs-CRP, p = 0.029) after excluding the participants with hs-CRP concentration of >10 mg L-1 and users of statins or anti-inflammatory therapy. In the CSO arm, there are significant genotype x diet interactions for n-3 polyunsaturated fatty acids, but not for the clinical characteristics. CONCLUSIONS: The FADS1 genotype modifies the response to high PUFA diets, especially to high-LA diet. These findings suggest that approaches considering FADS variation may be useful in personalized dietary counseling.
Authors: Floyd H Chilton; Ani Manichaikul; Chaojie Yang; Timothy D O'Connor; Laurel M Johnstone; Sarah Blomquist; Susan M Schembre; Susan Sergeant; Manja Zec; Michael Y Tsai; Stephen S Rich; Susan J Bridgewater; Rasika A Mathias; Brian Hallmark Journal: Front Nutr Date: 2022-02-08
Authors: Maija Vaittinen; Maria A Lankinen; Pirjo Käkelä; Jyrki Ågren; Craig E Wheelock; Markku Laakso; Ursula Schwab; Jussi Pihlajamäki Journal: Eur J Nutr Date: 2022-06-14 Impact factor: 4.865