Serkan Turan1, Fatma Ceren Sarioglu2, Ibrahim Mert Erbas3, Berrin Cavusoglu4, Ezgi Karagöz5, Ali Riza Şişman6, Sevay Alsen Güney5, Handan Güleryüz2, Ayhan Abaci3, Yesim Ozturk7, Aynur Pekcanlar Akay5. 1. Department of Child and Adolescent Psychiatry, Tekirdağ State Hospital, Tekirdağ, Turkey. drserkanturan@icloud.com. 2. Department of Radiology, Division of Pediatric Radiology, Dokuz Eylül University Medical Faculty, Izmir, Turkey. 3. Department of Pediatric Endocrinology, Faculty of Medicine, Dokuz Eylül University Medical Faculty, Izmir, Turkey. 4. Health Sciences Institutes, Department of Medical Physics, Institute of HealthSciences, Dokuz Eylül University, Izmir, Turkey. 5. Department of Child and Adolescent Psychiatry, Dokuz Eylül University Medical Faculty, Izmir, Turkey. 6. Department of Medical Microbiology, Dokuz Eylül University Medical Faculty, Izmir, Turkey. 7. Department of Pediatric Gastroenterology, Faculty of Medicine, Dokuz Eylül University Medical Faculty, Izmir, Turkey.
Abstract
PURPOSE: Binge eating disorder (BED) is characterized by frequent and persistent overeating episodes of binge eating without compensatory behaviors. The aim was to evaluate regional gray matter volume (GMV) abnormalities and appetite-regulating hormone levels (NPY and Leptin) in obese subjects either with or without BED compared to healthy controls (HC). METHODS: Twenty-six obese patients with BED, 25 obese patients without BED and 27 healthy subjects as an age-matched control group with neuroimaging and appetite-regulating hormone levels were found eligible for regional GMV abnormalities. A structural magnetic resonance scan and timely blood samples were drawn to assess the appetite-regulating hormone levels. RESULTS: The BED obese patients had a greater GMVs of the right medial orbitofrontal cortex (OFC) and the left medial OFC compared to the non-BED obese patients. BED patients were characterized by greater GMV of the left medial OFC than HCs. Relative to the HCs, higher serum NPY levels were found in BED obese and non-BED obese groups. Serum leptin levels (pg/mL) had positively correlations with GMV in right medial OFC, left medial OFC, right lateral OFC, and left anterior cingulate cortex. CONCLUSION: Among the reward processing network, which is largely associated with feeding behaviours in individuals with obesity and binge eating disorder, the OFC volumes was correlated with serum leptin concentrations. The results of our study may provide a rationale for exploring the link between regional grey matter volumes and appetite-related hormone levels in people with BED. LEVEL OF EVIDENCE: Level III, case-control analytic study.
PURPOSE:Binge eating disorder (BED) is characterized by frequent and persistent overeating episodes of binge eating without compensatory behaviors. The aim was to evaluate regional gray matter volume (GMV) abnormalities and appetite-regulating hormone levels (NPY and Leptin) in obese subjects either with or without BED compared to healthy controls (HC). METHODS: Twenty-six obesepatients with BED, 25 obesepatients without BED and 27 healthy subjects as an age-matched control group with neuroimaging and appetite-regulating hormone levels were found eligible for regional GMV abnormalities. A structural magnetic resonance scan and timely blood samples were drawn to assess the appetite-regulating hormone levels. RESULTS: The BED obesepatients had a greater GMVs of the right medial orbitofrontal cortex (OFC) and the left medial OFC compared to the non-BED obesepatients. BEDpatients were characterized by greater GMV of the left medial OFC than HCs. Relative to the HCs, higher serum NPY levels were found in BED obese and non-BED obese groups. Serum leptin levels (pg/mL) had positively correlations with GMV in right medial OFC, left medial OFC, right lateral OFC, and left anterior cingulate cortex. CONCLUSION: Among the reward processing network, which is largely associated with feeding behaviours in individuals with obesity and binge eating disorder, the OFC volumes was correlated with serum leptin concentrations. The results of our study may provide a rationale for exploring the link between regional grey matter volumes and appetite-related hormone levels in people with BED. LEVEL OF EVIDENCE: Level III, case-control analytic study.
Authors: Deborah R Glasofer; Marian Tanofsky-Kraff; Kamryn T Eddy; Susan Z Yanovski; Kelly R Theim; Margaret C Mirch; Samareh Ghorbani; Lisa M Ranzenhofer; David Haaga; Jack A Yanovski Journal: J Pediatr Psychol Date: 2006-06-25
Authors: Ronald C Kessler; Patricia A Berglund; Wai Tat Chiu; Anne C Deitz; James I Hudson; Victoria Shahly; Sergio Aguilar-Gaxiola; Jordi Alonso; Matthias C Angermeyer; Corina Benjet; Ronny Bruffaerts; Giovanni de Girolamo; Ron de Graaf; Josep Maria Haro; Viviane Kovess-Masfety; Siobhan O'Neill; Jose Posada-Villa; Carmen Sasu; Kate Scott; Maria Carmen Viana; Miguel Xavier Journal: Biol Psychiatry Date: 2013-01-03 Impact factor: 13.382
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