Joana Maria Almeida Osório1, Borja Rodríguez-Herreros1, David Romascano1, Vincent Junod1, Aline Habegger1, Aurélie Pain1, Sonia Richetin1, Paola Yu1,2, Bertrand Isidor3, Lionel Van Maldergem4,5,6, Linda Pons7, Sabine Manificat1, Nadia Chabane1, Marine Jequier Gygax1, Anne Manuela Maillard8. 1. CHUV-Centre Hospitalier Universitaire Vaudois, Service des Troubles du Spectre de l'Autisme et apparentés, Lausanne University Hospital, Les Allières - Av. Beaumont 23, 1011, Lausanne, Switzerland. 2. Laboratory for Investigative Neurophysiology (LINE), Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. 3. Service de Génétique Médicale, CHU-Nantes, Nantes, France. 4. Centre de Génétique Humaine, Centre Hospitalier Régional Universitaire, Université de Franche-Comté, Besançon, France. 5. Unité de recherche en neurosciences intégratives et cognitives EA481, Université de Franche-Comté, Besançon, France. 6. Centre d'investigation clinique 1431, INSERM, Besançon, France. 7. Service Génopsy - Pôle Hospitalo-Universitaire ADIS, Centre hospitalier Le Vinatier, Bron, France. 8. CHUV-Centre Hospitalier Universitaire Vaudois, Service des Troubles du Spectre de l'Autisme et apparentés, Lausanne University Hospital, Les Allières - Av. Beaumont 23, 1011, Lausanne, Switzerland. Anne.Maillard@chuv.ch.
Abstract
BACKGROUND: Sensory processing atypicalities are frequent in Autism Spectrum Disorder (ASD) and neurodevelopmental disorders (NDD). Different domains of sensory processing appear to be differentially altered in these disorders. In this study, we explored the sensory profile of two clinical cohorts, in comparison with a sample of typically developing children. METHODS: Behavioral responses to sensory stimuli were assessed using the Sensory Processing Measure (parent-report questionnaire). We included 121 ASD children, 17 carriers of the 16p11.2 deletion (Del 16p11.2) and 45 typically developing (TD) children. All participants were aged between 2 and 12 years. Additional measures included the Tactile Defensiveness and Discrimination Test-Revised, Wechsler Intelligence Scales and Autism Diagnostic Observation Schedule (ADOS-2). Statistical analyses included MANCOVA and regression analyses. RESULTS: ASD children score significantly higher on all SPM subscales compared to TD. Del16p11.2 also scored higher than TD on all subscales except for tactile and olfactory/taste processing, in which they score similarly to TD. When assessing sensory modulation patterns (hyper-, hypo-responsiveness and seeking), ASD did not significantly differ from del16p11.2. Both groups had significantly higher scores across all patterns than the TD group. There was no significant association between the SPM Touch subscale and the TDDT-R. LIMITATIONS: Sensory processing was assessed using a parent-report questionnaire. Even though it captures observable behavior, a questionnaire does not assess sensory processing in all its complexity. The sample size of the genetic cohort and the small subset of ASD children with TDDT-R data render some of our results exploratory. Divergence between SPM Touch and TDDT-R raises important questions about the nature of the process that is assessed. CONCLUSIONS: Touch and olfaction/taste seem to be particularly affected in ASD children compared to del16p11.2. These results indicate that parent report measures can provide a useful perspective on behavioral expression. Sensory phenotyping, when combined with neurobiological and psychophysical methods, might have the potential to provide a better understanding of the sensory processing in ASD and in other NDD.
BACKGROUND: Sensory processing atypicalities are frequent in Autism Spectrum Disorder (ASD) and neurodevelopmental disorders (NDD). Different domains of sensory processing appear to be differentially altered in these disorders. In this study, we explored the sensory profile of two clinical cohorts, in comparison with a sample of typically developing children. METHODS: Behavioral responses to sensory stimuli were assessed using the Sensory Processing Measure (parent-report questionnaire). We included 121 ASD children, 17 carriers of the 16p11.2 deletion (Del 16p11.2) and 45 typically developing (TD) children. All participants were aged between 2 and 12 years. Additional measures included the Tactile Defensiveness and Discrimination Test-Revised, Wechsler Intelligence Scales and Autism Diagnostic Observation Schedule (ADOS-2). Statistical analyses included MANCOVA and regression analyses. RESULTS: ASD children score significantly higher on all SPM subscales compared to TD. Del16p11.2 also scored higher than TD on all subscales except for tactile and olfactory/taste processing, in which they score similarly to TD. When assessing sensory modulation patterns (hyper-, hypo-responsiveness and seeking), ASD did not significantly differ from del16p11.2. Both groups had significantly higher scores across all patterns than the TD group. There was no significant association between the SPM Touch subscale and the TDDT-R. LIMITATIONS: Sensory processing was assessed using a parent-report questionnaire. Even though it captures observable behavior, a questionnaire does not assess sensory processing in all its complexity. The sample size of the genetic cohort and the small subset of ASD children with TDDT-R data render some of our results exploratory. Divergence between SPM Touch and TDDT-R raises important questions about the nature of the process that is assessed. CONCLUSIONS: Touch and olfaction/taste seem to be particularly affected in ASD children compared to del16p11.2. These results indicate that parent report measures can provide a useful perspective on behavioral expression. Sensory phenotyping, when combined with neurobiological and psychophysical methods, might have the potential to provide a better understanding of the sensory processing in ASD and in other NDD.
Authors: Mu Yang; Elena J Mahrt; Freeman Lewis; Gillian Foley; Thomas Portmann; Ricardo E Dolmetsch; Christine V Portfors; Jacqueline N Crawley Journal: Autism Res Date: 2015-02-07 Impact factor: 5.216
Authors: Ayelet Ben-Sasson; Sharon A Cermak; Gael I Orsmond; Helen Tager-Flusberg; Alice S Carter; Mary Beth Kadlec; Winnie Dunn Journal: Am J Occup Ther Date: 2007 Sep-Oct
Authors: Andrew J D Crow; Jennica M Janssen; Kayci L Vickers; Julia Parish-Morris; Paul J Moberg; David R Roalf Journal: J Autism Dev Disord Date: 2020-08
Authors: A M Maillard; A Ruef; F Pizzagalli; E Migliavacca; L Hippolyte; S Adaszewski; J Dukart; C Ferrari; P Conus; K Männik; M Zazhytska; V Siffredi; P Maeder; Z Kutalik; F Kherif; N Hadjikhani; J S Beckmann; A Reymond; B Draganski; S Jacquemont Journal: Mol Psychiatry Date: 2014-11-25 Impact factor: 15.992