Morgane Guillou-Landreat1,2,3, Antoine Dany2, Gaëlle Challet-Bouju1,4, Edouard Laforgue1,4, Juliette Leboucher4, Jean Benoit Hardouin1, Caroline Victorri-Vigneau1,5, Marie Grall-Bronnec1,3,4. 1. INSERM UMR 1246, SPHERE, Methods in Patient-Centered Outcomes and Health Research, Nantes and Tours Universities, 44000 Nantes, France. 2. EA 7479 SPURBO, Universite Bretagne Occidentale, 29200 Brest, France. 3. HUGOPSY Network, 35000 Rennes, France. 4. CHU Nantes, Addictology and Psychiatry Department, Nantes University Hospital, 44000 Nantes, France. 5. CHU Nantes, Pharmacology Department, Nantes University Hospital, 44000 Nantes, France.
Abstract
(1) Background: Opioid use disorder (OUD) is a complex condition that can require long-term treatment. Pharmacological therapy for OUD involves treatment with opioid agonists (OMT) tailored to individual profiles. The aim of our study in daily clinical practice was to compare the profiles of patients treated with methadone (MTD) and those using buprenorphine (BHD or BHD-naloxone-NX). (2) Methods: A cross-sectional multicentre study explored the psychological, somatic and social profiles of patients with Opioid Use Disorder (OUD) following Opioid Maintenance Treatment (BHD, BHD/NX, or MTD). Descriptive and comparative analyses were performed. (3) Results: 257 patients were included, a majority were men using heroin. A total of 68% (178) were on MTD, 32% (79) were on BHD. Patients with MTD were significantly more likely to report somatic damage, and more likely to be younger and not to report oral or sublingual use as the main route for heroin or non-medical opioids. (4) Conclusions: In daily clinical practice, somatic damage was significantly more severe among MTD patients. Age and route of administration also differed, and our results could raise the issue of the type of OMT prescribed in case of non-medical use of prescribed opioids. These hypothesis should be confirmed in larger studies.
(1) Background: Opioid use disorder (OUD) is a complex condition that can require long-term treatment. Pharmacological therapy for OUD involves treatment with opioid agonists (OMT) tailored to individual profiles. The aim of our study in daily clinical practice was to compare the profiles of patients treated with methadone (MTD) and those using buprenorphine (BHD or BHD-naloxone-NX). (2) Methods: A cross-sectional multicentre study explored the psychological, somatic and social profiles of patients with Opioid Use Disorder (OUD) following Opioid Maintenance Treatment (BHD, BHD/NX, or MTD). Descriptive and comparative analyses were performed. (3) Results: 257 patients were included, a majority were men using heroin. A total of 68% (178) were on MTD, 32% (79) were on BHD. Patients with MTD were significantly more likely to report somatic damage, and more likely to be younger and not to report oral or sublingual use as the main route for heroin or non-medical opioids. (4) Conclusions: In daily clinical practice, somatic damage was significantly more severe among MTD patients. Age and route of administration also differed, and our results could raise the issue of the type of OMT prescribed in case of non-medical use of prescribed opioids. These hypothesis should be confirmed in larger studies.
Authors: Maurice Dematteis; Marc Auriacombe; Oscar D'Agnone; Lorenzo Somaini; Néstor Szerman; Richard Littlewood; Farrukh Alam; Hannu Alho; Amine Benyamina; Julio Bobes; Jean Pierre Daulouede; Claudio Leonardi; Icro Maremmani; Marta Torrens; Stephan Walcher; Michael Soyka Journal: Expert Opin Pharmacother Date: 2017-12-03 Impact factor: 3.889
Authors: Deborah S Hasin; Charles P O'Brien; Marc Auriacombe; Guilherme Borges; Kathleen Bucholz; Alan Budney; Wilson M Compton; Thomas Crowley; Walter Ling; Nancy M Petry; Marc Schuckit; Bridget F Grant Journal: Am J Psychiatry Date: 2013-08 Impact factor: 18.112