Literature DB >> 33546409

The Mitochondrial Kinase PINK1 in Diabetic Kidney Disease.

Chunling Huang1, Ji Bian1, Qinghua Cao1, Xin-Ming Chen1, Carol A Pollock1.   

Abstract

Mitochondria are critical organelles that play a key role in cellular metabolism, survival, and homeostasis. Mitochondrial dysfunction has been implicated in the pathogenesis of diabetic kidney disease. The function of mitochondria is critically regulated by several mitochondrial protein kinases, including the phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1). The focus of PINK1 research has been centered on neuronal diseases. Recent studies have revealed a close link between PINK1 and many other diseases including kidney diseases. This review will provide a concise summary of PINK1 and its regulation of mitochondrial function in health and disease. The physiological role of PINK1 in the major cells involved in diabetic kidney disease including proximal tubular cells and podocytes will also be summarized. Collectively, these studies suggested that targeting PINK1 may offer a promising alternative for the treatment of diabetic kidney disease.

Entities:  

Keywords:  PINK1; diabetic kidney disease; mitochondria; mitochondria quality control; mitophagy

Mesh：

Substances：

Year:  2021        PMID： 33546409      PMCID： PMC7913536          DOI： 10.3390/ijms22041525

Source DB:  PubMed          Journal:  Int J Mol Sci        ISSN： 1422-0067            Impact factor:   5.923


  89 in total

1.  Cytosolic cleaved PINK1 represses Parkin translocation to mitochondria and mitophagy.

Authors:  Maja A Fedorowicz; Rosa L A de Vries-Schneider; Cornelia Rüb; Dorothea Becker; Yong Huang; Chun Zhou; Dana M Alessi Wolken; Wolfgang Voos; Yuhui Liu; Serge Przedborski
Journal:  EMBO Rep       Date:  2013-12-15       Impact factor: 8.807

Review 2.  PINK1 activation-turning on a promiscuous kinase.

Authors:  Liesbeth Aerts; Bart De Strooper; Vanessa A Morais
Journal:  Biochem Soc Trans       Date:  2015-04       Impact factor: 5.407

Review 3.  Renal tubule injury: a driving force toward chronic kidney disease.

Authors:  Bi-Cheng Liu; Tao-Tao Tang; Lin-Li Lv; Hui-Yao Lan
Journal:  Kidney Int       Date:  2018-01-17       Impact factor: 10.612

4.  MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A.

Authors:  Agostinho G Rocha; Antonietta Franco; Andrzej M Krezel; Jeanne M Rumsey; Justin M Alberti; William C Knight; Nikolaos Biris; Emmanouil Zacharioudakis; James W Janetka; Robert H Baloh; Richard N Kitsis; Daria Mochly-Rosen; R Reid Townsend; Evripidis Gavathiotis; Gerald W Dorn
Journal:  Science       Date:  2018-04-20       Impact factor: 47.728

5.  PINK1/Parkin mediated mitophagy ameliorates palmitic acid-induced apoptosis through reducing mitochondrial ROS production in podocytes.

Authors:  Xu-Shun Jiang; Xue-Mei Chen; Wei Hua; Jun-Ling He; Ting Liu; Xun-Jia Li; Jiang-Min Wan; Hua Gan; Xiao-Gang Du
Journal:  Biochem Biophys Res Commun       Date:  2020-03-12       Impact factor: 3.575

6.  Chronic treatment with the complex I inhibitor MPP+ depletes endogenous PTEN-induced kinase 1 (PINK1) via up-regulation of Bcl-2-associated athanogene 6 (BAG6).

Authors:  Manish Verma; Jianhui Zhu; Kent Z Q Wang; Charleen T Chu
Journal:  J Biol Chem       Date:  2020-04-24       Impact factor: 5.157

7.  Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin.

Authors:  Atsushi Tanaka; Megan M Cleland; Shan Xu; Derek P Narendra; Der-Fen Suen; Mariusz Karbowski; Richard J Youle
Journal:  J Cell Biol       Date:  2010-12-20       Impact factor: 10.539

8.  PINK1 Interacts with VCP/p97 and Activates PKA to Promote NSFL1C/p47 Phosphorylation and Dendritic Arborization in Neurons.

Authors:  Kent Z Q Wang; Erin Steer; P Anthony Otero; Nicholas W Bateman; Mary Hongying Cheng; Ana Ligia Scott; Christine Wu; Ivet Bahar; Yu-Tzu Shih; Yi-Ping Hsueh; Charleen T Chu
Journal:  eNeuro       Date:  2018-01-10

9.  Astragaloside IV ameliorates diabetic nephropathy by modulating the mitochondrial quality control network.

Authors:  Xinhui Liu; Wenjing Wang; Gaofeng Song; Xian Wei; Youjia Zeng; Pengxun Han; Dongtao Wang; Mumin Shao; Juan Wu; Huili Sun; Guoliang Xiong; Shunmin Li
Journal:  PLoS One       Date:  2017-08-02       Impact factor: 3.240

10.  PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72.

Authors:  Sophie Vieweg; Katie Mulholland; Bastian Bräuning; Nitin Kachariya; Yu-Chiang Lai; Rachel Toth; Pawan Kishor Singh; Ilaria Volpi; Michael Sattler; Michael Groll; Aymelt Itzen; Miratul M K Muqit
Journal:  Biochem J       Date:  2020-05-15       Impact factor: 3.857
View more
  3 in total

1.  Src Activation Aggravates Podocyte Injury in Diabetic Nephropathy via Suppression of FUNDC1-Mediated Mitophagy.

Authors:  Ting Zheng; Han-Yu Wang; Yang Chen; Xiao Chen; Zi-Ling Wu; Qin-Yu Hu; Hui Sun
Journal:  Front Pharmacol       Date:  2022-05-09       Impact factor: 5.988

Review 2.  The Mitochondrial-Associated Endoplasmic Reticulum Membrane and Its Role in Diabetic Nephropathy.

Authors:  Lihua Ni; Cheng Yuan
Journal:  Oxid Med Cell Longev       Date:  2021-11-05       Impact factor: 6.543

Review 3.  Therapeutic Potential of Photobiomodulation for Chronic Kidney Disease.

Authors:  Ji Bian; Ann Liebert; Brian Bicknell; Xin-Ming Chen; Chunling Huang; Carol A Pollock
Journal:  Int J Mol Sci       Date:  2022-07-21       Impact factor: 6.208
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.