Literature DB >> 33546349

Disturbance in Mammalian Cognition Caused by Accumulation of Silver in Brain.

Anna A Antsiferova1,2, Marina Yu Kopaeva1, Vyacheslav N Kochkin1, Pavel K Kashkarov1,3, Mikhail V Kovalchuk1,3.   

Abstract

The influence of daily prolonged administration of silver nanoparticles on the cognitive functions of a model mammal was studied. The accumulation of silver in the whole brain and the hippocampus, cerebellum, cortex and residual brain tissue of the mouse was investigated by highly precise and representative neutron activation analysis, and histological studies were conducted. Here, we show that long-term memory impairments were caused by the accumulation of silver nanoparticles in the brain and its subregions, such as the hippocampus, cerebellum and cortex, in a step-like manner by disturbance of hippocampal cell integrity. Three different approaches allowed us to observe this phenomenon and discover the reasons it occurred.

Entities:  

Keywords:  CA2; accumulation in brain; biodistribution; cerebellum; contextual memory; cortex; fear; hippocampus; neutron activation analysis; silver nanoparticles

Year:  2021        PMID： 33546349      PMCID： PMC7913520          DOI： 10.3390/toxics9020030

Source DB:  PubMed          Journal:  Toxics        ISSN： 2305-6304


  38 in total

1.  Augmented antibacterial activity of ampicillin with silver nanoparticles against methicillin-resistant Staphylococcus aureus (MRSA).

Authors:  Priyanka Surwade; Christopher Ghildyal; Chase Weikel; Todd Luxton; Derek Peloquin; Xin Fan; Vishal Shah
Journal:  J Antibiot (Tokyo)       Date:  2018-10-25       Impact factor: 2.649

Review 2.  Biomolecular coronas provide the biological identity of nanosized materials.

Authors:  Marco P Monopoli; Christoffer Aberg; Anna Salvati; Kenneth A Dawson
Journal:  Nat Nanotechnol       Date:  2012-12       Impact factor: 39.213

3.  Silver nanoparticles from leaf extract of Mentha piperita: Eco-friendly synthesis and effect on acetylcholinesterase activity.

Authors:  Aisha Khatoon; Farheen Khan; Nabeel Ahmad; Sibhghatulla Shaikh; Syed Mohd Danish Rizvi; Shazi Shakil; Mohammad H Al-Qahtani; Adel M Abuzenadah; Shams Tabrez; Abo Bakr Fathy Ahmed; Ahmed Alafnan; Hayatul Islam; Danish Iqbal; Rajiv Dutta
Journal:  Life Sci       Date:  2018-08-20       Impact factor: 5.037

4.  Accumulation of silver nanoparticles by cultured primary brain astrocytes.

Authors:  Eva M Luther; Yvonne Koehler; Joerg Diendorf; Matthias Epple; Ralf Dringen
Journal:  Nanotechnology       Date:  2011-08-18       Impact factor: 3.874

5.  Role of Hippocampal CA2 Region in Triggering Sharp-Wave Ripples.

Authors:  Azahara Oliva; Antonio Fernández-Ruiz; György Buzsáki; Antal Berényi
Journal:  Neuron       Date:  2016-09-01       Impact factor: 17.173

6.  Neurotoxicity of Silver Nanoparticles in Rat Brain After Intragastric Exposure.

Authors:  Liming Xu; Anliang Shao; Yanhong Zhao; Zhijie Wang; Cuiping Zhang; Yilin Sun; Jie Deng; Laisheng Lee Chou
Journal:  J Nanosci Nanotechnol       Date:  2015-06

Review 7.  Ammon's Horn 2 (CA2) of the Hippocampus: A Long-Known Region with a New Potential Role in Neurodegeneration.

Authors:  Cindy Chi-Ching Pang; Clemens Kiecker; John T O'Brien; Wendy Noble; Raymond Chuen-Chung Chang
Journal:  Neuroscientist       Date:  2018-06-05       Impact factor: 7.519

Review 8.  Perspectives for the use of silver nanoparticles in dental practice.

Authors:  René García-Contreras; Liliana Argueta-Figueroa; Cynthia Mejía-Rubalcava; Rocio Jiménez-Martínez; Sahamanta Cuevas-Guajardo; Paola Ariselda Sánchez-Reyna; Hugo Mendieta-Zeron
Journal:  Int Dent J       Date:  2011-11-08       Impact factor: 2.607

9.  Effects of silver nanoparticles on primary mixed neural cell cultures: uptake, oxidative stress and acute calcium responses.

Authors:  Andrea Haase; Stephanie Rott; Alexandre Mantion; Philipp Graf; Johanna Plendl; Andreas F Thünemann; Wolfgang P Meier; Andreas Taubert; Andreas Luch; Georg Reiser
Journal:  Toxicol Sci       Date:  2012-01-12       Impact factor: 4.849

10.  Social and novel contexts modify hippocampal CA2 representations of space.

Authors:  Georgia M Alexander; Shannon Farris; Jason R Pirone; Chenguang Zheng; Laura L Colgin; Serena M Dudek
Journal:  Nat Commun       Date:  2016-01-25       Impact factor: 14.919
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  2 in total

Review 1.  Applications of Silver Nanoparticles in Dentistry: Advances and Technological Innovation.

Authors:  Clara Couto Fernandez; Ana Rita Sokolonski; Maísa Santos Fonseca; Danijela Stanisic; Danilo Barral Araújo; Vasco Azevedo; Ricardo Dias Portela; Ljubica Tasic
Journal:  Int J Mol Sci       Date:  2021-03-02       Impact factor: 5.923

2.  Kinetics of Silver Accumulation in Tissues of Laboratory Mice after Long-Term Oral Administration of Silver Nanoparticles.

Authors:  Anna A Antsiferova; Marina Yu Kopaeva; Vyacheslav N Kochkin; Pavel K Kashkarov
Journal:  Nanomaterials (Basel)       Date:  2021-11-26       Impact factor: 5.076
  2 in total

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