Cong Gai1, Tianyao Qiang2,3, Yuxin Zhang1, Yuan Chai4, Wandi Feng1, Hongmei Sun1. 1. Department of Anatomy, School of Preclinical Medicine, Beijing University of Chinese Medicine. 2. Department of Research and Education, Beijing Ditan Hospital, Capital Medical University. 3. Department of Integrated Chinese and Western medicine, Northern Sichuan Medical College, Nanchong, Sichuan. 4. Dongfang Hospital Beijing University of Chinese Medicine, Beijing, China.
Abstract
BACKGROUND: Parkinson disease (PD) is a worldwide spread neurodegenerative disorder. Dopamine replacement therapy is currently the mainstream treatment, which can alleviate the symptoms but induces motor complications. Electroacupuncture (EA) is beneficial for PD as an alternative medicine. However, few reliable clinical trials or objective systematic reviews are available to give a verdict on the effectiveness of EA in the treatment of PD. Thus, we evaluate the evidence for EA in PD patients by conducting this meta-analysis. METHODS: PubMed, Cochrane Library, EMBASE, China National Knowledge Infrastructure, Chinese Scientific and Technology Journal database, WanFang Digital Periodicals, and Chinese Biomedical Literature Database (SinoMed) will be systematically searched for evidence by 2 authors individually. The analysis will be conducted by RevMan 5.3 software according to Cochrane Handbook. RESULTS: The efficacy and safety of EA for PD will be comprehensively assessed from the outcomes, including the effectiveness rate, scores of Unified Parkinson Disease Rating Scale, and Webster scale, superoxide dismutase, lipid peroxides, and dopamine content. CONCLUSION: This systematic review will provide evidence for whether EA can treatment PD. REGISTRATION INFORMATION: PROSPERO CRD42019120956.
BACKGROUND:Parkinson disease (PD) is a worldwide spread neurodegenerative disorder. Dopamine replacement therapy is currently the mainstream treatment, which can alleviate the symptoms but induces motor complications. Electroacupuncture (EA) is beneficial for PD as an alternative medicine. However, few reliable clinical trials or objective systematic reviews are available to give a verdict on the effectiveness of EA in the treatment of PD. Thus, we evaluate the evidence for EA in PDpatients by conducting this meta-analysis. METHODS: PubMed, Cochrane Library, EMBASE, China National Knowledge Infrastructure, Chinese Scientific and Technology Journal database, WanFang Digital Periodicals, and Chinese Biomedical Literature Database (SinoMed) will be systematically searched for evidence by 2 authors individually. The analysis will be conducted by RevMan 5.3 software according to Cochrane Handbook. RESULTS: The efficacy and safety of EA for PD will be comprehensively assessed from the outcomes, including the effectiveness rate, scores of Unified Parkinson Disease Rating Scale, and Webster scale, superoxide dismutase, lipid peroxides, and dopamine content. CONCLUSION: This systematic review will provide evidence for whether EA can treatment PD. REGISTRATION INFORMATION: PROSPERO CRD42019120956.
Authors: Malk Eun Pak; Sung Min Ahn; Da Hee Jung; Hong Ju Lee; Ki Tae Ha; Hwa Kyoung Shin; Byung Tae Choi Journal: J Gerontol A Biol Sci Med Sci Date: 2020-03-09 Impact factor: 6.053