Literature DB >> 33545076

Clinical Trial for Parkinson's Disease Gets a Green Light in the US.

Jun Takahashi1.   

Abstract

Cell-based therapy is expected as an alternative treatment for Parkinson's disease. In this issue of Cell Stem Cell, two accompanying papers (Kim et al., 2021; Piao et al., 2021) report the induction of clinically applicable dopaminergic neurons from human embryonic stem cells and the results of pre-clinical study toward a clinical trial.
Copyright © 2021 Elsevier Inc. All rights reserved.

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Year:  2021        PMID： 33545076     DOI： 10.1016/j.stem.2021.01.013

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  5 in total

1.  Generation of hypoimmunogenic induced pluripotent stem cells by CRISPR-Cas9 system and detailed evaluation for clinical application.

Authors:  Yuko Kitano; Sayaka Nishimura; Tomoaki M Kato; Anna Ueda; Kaho Takigawa; Masafumi Umekage; Masaki Nomura; Ayane Kawakami; Haruna Ogawa; Huaigeng Xu; Akitsu Hotta; Naoko Takasu; Masayoshi Tsukahara
Journal:  Mol Ther Methods Clin Dev       Date:  2022-05-29       Impact factor: 5.849

2.  Gut microbiota relieves inflammation in the substantia nigra of chronic Parkinson's disease by protecting the function of dopamine neurons.

Authors:  Tian Zhang; Tan Wang; Xinxu Chen; Zhenqiang Zhao; Zhibin Chen
Journal:  Exp Ther Med       Date:  2021-11-16       Impact factor: 2.447

Review 3.  Motor neuron replacement therapy for amyotrophic lateral sclerosis.

Authors:  Bochao Liu; Mo Li; Lingyan Zhang; Zhiguo Chen; Paul Lu
Journal:  Neural Regen Res       Date:  2022-08       Impact factor: 5.135

4.  Human midbrain dopaminergic neuronal differentiation markers predict cell therapy outcomes in a Parkinson's disease model.

Authors:  Peibo Xu; Hui He; Qinqin Gao; Yingying Zhou; Ziyan Wu; Xiao Zhang; Linyu Sun; Gang Hu; Qian Guan; Zhiwen You; Xinyue Zhang; Wenping Zheng; Man Xiong; Yuejun Chen
Journal:  J Clin Invest       Date:  2022-07-15       Impact factor: 19.456

Review 5.  Bringing Advanced Therapies for Parkinson's Disease to the Clinic: The Scientist's Perspective.

Authors:  Mark Tomishima; Agnete Kirkeby
Journal:  J Parkinsons Dis       Date:  2021       Impact factor: 5.568
  5 in total

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