Mona Hussein1, Wael Fathy2, Ragaey A Eid3, Hoda M Abdel-Hamid4, Ahmed Yehia5, Mostafa Sheemy6, Christine Ragaie7, Ahmed Dahshan8, Hoda I Rizk9, Nabila Laz10, Rehab Magdy8. 1. Associate Professor of Neurology, Department of Neurology, Beni-Suef University, Beni-Suef, Egypt. 2. Lecturer of, Anaesthesia, Surgical ICU and Pain management, Department of Anaesthesia, Surgical ICU and Pain manageme, nt, Beni-Suef University, Beni-Suef, Egypt. 3. Lecturer of Tropical medicine, Department of Tropical medicine, Beni-suef University, Beni-Suef, Egypt. 4. Lecturer of Chest diseases, Cairo University, Cairo, Egypt. 5. Lecturer of Internal medicine, Department of Internal medicine, Beni-suef University, Beni-Suef, Egypt. 6. Lecturer of Medical Microbiology and Immunology, Department of Medical Microbiology and Immunology, Beni-suef University, Beni-Suef, Egypt. 7. Assistant Lecturer of Neurology, Department of Neurology, Cairo University, Cairo, Egypt. 8. Lecturer of Neurology, Department of Neurology, Cairo University, Cairo, Egypt. 9. Associate Professor of Public Health and Community Medicine, Cairo University, Cairo, Egypt. 10. Professor of Chest diseases, Department of Chest diseases, Beni-Suef University, Beni-Suef, Egypt.
Abstract
OBJECTIVES: Headache is considered one of the most frequent neurological manifestations of COVID-19. This work aimed to identify the relative frequency of COVID-19 related headache and to clarify the impact of clinical, laboratory findings of COVID-19 infection on headache occurrence and its response to analgesics. DESIGN: Cross-sectional study. SETTING: Recovered COVID-19 patients. SUBJECTS: 782 patients with a confirmed diagnosis of COVID-19 infection. METHODS: Clinical, laboratory and imaging data were obtained from the hospital medical records. Regarding patients who developed COVID-19 related headache, a trained neurologist performed an analysis of headache and its response to analgesics. RESULTS: The relative frequency of COVID-19 related headache among our sample was 55.1% with 95% CI (0.516-0.586) for the estimated population prevalence. Female gender, malignancy, primary headache, fever, dehydration, lower levels of hemoglobin and platelets and higher levels of neutrophil/lymphocyte ratio (NLR) and CRP were significantly associated with COVID-19 related headache. Multivariate analysis revealed that female gender, fever, dehydration, primary headache, high NLR, and decreased platelet count were independent predictors of headache occurrence. By evaluating headache response to analgesics, old age, diabetes, hypertension, primary headache, severe COVID-19, steroid intake, higher CRP and ferritin and lower hemoglobin levels were associated with poor response to analgesics. Multivariate analysis revealed that primary headache, steroids intake, moderate and severe COVID-19 were independent predictors of non-response to analgesics. DISCUSSION: Headache occurs in 55.1% of patients with COVID-19. Female gender, fever, dehydration, primary headache, high NLR, and decreased platelet count are considered independent predictors of COVID-19 related headache.
OBJECTIVES:Headache is considered one of the most frequent neurological manifestations of COVID-19. This work aimed to identify the relative frequency of COVID-19 related headache and to clarify the impact of clinical, laboratory findings of COVID-19infection on headache occurrence and its response to analgesics. DESIGN: Cross-sectional study. SETTING: Recovered COVID-19patients. SUBJECTS: 782 patients with a confirmed diagnosis of COVID-19infection. METHODS: Clinical, laboratory and imaging data were obtained from the hospital medical records. Regarding patients who developed COVID-19 related headache, a trained neurologist performed an analysis of headache and its response to analgesics. RESULTS: The relative frequency of COVID-19 related headache among our sample was 55.1% with 95% CI (0.516-0.586) for the estimated population prevalence. Female gender, malignancy, primary headache, fever, dehydration, lower levels of hemoglobin and platelets and higher levels of neutrophil/lymphocyte ratio (NLR) and CRP were significantly associated with COVID-19 related headache. Multivariate analysis revealed that female gender, fever, dehydration, primary headache, high NLR, and decreased platelet count were independent predictors of headache occurrence. By evaluating headache response to analgesics, old age, diabetes, hypertension, primary headache, severe COVID-19, steroid intake, higher CRP and ferritin and lower hemoglobin levels were associated with poor response to analgesics. Multivariate analysis revealed that primary headache, steroids intake, moderate and severe COVID-19 were independent predictors of non-response to analgesics. DISCUSSION: Headache occurs in 55.1% of patients with COVID-19. Female gender, fever, dehydration, primary headache, high NLR, and decreased platelet count are considered independent predictors of COVID-19 related headache.
Authors: Pedro Augusto Sampaio Rocha-Filho; Pedro Mota Albuquerque; Larissa Clementino Leite Sá Carvalho; Mylana Dandara Pereira Gama; João Eudes Magalhães Journal: J Headache Pain Date: 2022-01-03 Impact factor: 7.277
Authors: Yannick Fogoum Fogang; Michel Noubom; Pierre-Yves Bassong; Paul Chimi Mbonda; Iliassou Njoudap Mfopou; Daniel Massi Gams; Callixte Tegueu Kuate; Joseph Kamtchum-Tatuene Journal: Pan Afr Med J Date: 2021-04-05