Literature DB >> 33544194

The role of microglia in chronic pain and depression: innocent bystander or culprit?

Nan Yin1, Enshi Yan1, Wenbin Duan2, Changyuan Mao2, Qin Fei2, Chun Yang3, Yimin Hu4, Xiaolin Xu5.   

Abstract

Clinical evidence shows that chronic pain and depression often accompany each other, but the underlying pathogenesis of comorbid chronic pain and depression remains mostly undetermined. Biotechnology is gradually revealing the phenotype and function of microglia, with great progress regarding microglia's role in neurodegeneration, depression, chronic pain, and other conditions. This article summarizes the role of microglia in chronic pain, depression, and comorbidities, which is conducive to finding new targets to treat chronic pain and depression.

Entities:  

Keywords:  Chronic pain; Depression; Microglia

Mesh：

Year:  2021        PMID： 33544194     DOI： 10.1007/s00213-021-05780-4

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  97 in total

1.  P2X4 receptor channels form large noncytolytic pores in resting and activated microglia.

Authors:  Louis-Philippe Bernier; Ariel R Ase; Eric Boué-Grabot; Philippe Séguéla
Journal:  Glia       Date:  2012-02-08       Impact factor: 7.452

2.  Inhibition of P2X4 function by P2Y6 UDP receptors in microglia.

Authors:  Louis-Philippe Bernier; Ariel R Ase; Éric Boué-Grabot; Philippe Séguéla
Journal:  Glia       Date:  2013-10-07       Impact factor: 7.452

Review 3.  Microglial Signaling in Chronic Pain with a Special Focus on Caspase 6, p38 MAP Kinase, and Sex Dependence.

Authors:  T Berta; Y J Qadri; G Chen; R R Ji
Journal:  J Dent Res       Date:  2016-06-15       Impact factor: 6.116

4.  Minocycline modulates neuropathic pain behaviour and cortical M1-M2 microglial gene expression in a rat model of depression.

Authors:  Nikita N Burke; Daniel M Kerr; Orla Moriarty; David P Finn; Michelle Roche
Journal:  Brain Behav Immun       Date:  2014-06-30       Impact factor: 7.217

5.  Lower hippocampal volume in patients suffering from depression: a meta-analysis.

Authors:  Stephanie Campbell; Michael Marriott; Claude Nahmias; Glenda M MacQueen
Journal:  Am J Psychiatry       Date:  2004-04       Impact factor: 18.112

6.  P2X4R+ microglia drive neuropathic pain.

Authors:  Simon Beggs; Tuan Trang; Michael W Salter
Journal:  Nat Neurosci       Date:  2012-07-26       Impact factor: 24.884

7.  Depression symptoms and chronic pain in the community population in Beijing, China.

Authors:  Xi Chen; Hui Green Cheng; Yueqin Huang; Zhaorui Liu; Xiaomin Luo
Journal:  Psychiatry Res       Date:  2012-05-05       Impact factor: 3.222

Review 8.  The potential of P2X7 receptors as a therapeutic target, including inflammation and tumour progression.

Authors:  Geoffrey Burnstock; Gillian E Knight
Journal:  Purinergic Signal       Date:  2017-11-21       Impact factor: 3.765

9.  Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway.

Authors:  Burak I Arioz; Bora Tastan; Emre Tarakcioglu; Kemal Ugur Tufekci; Melis Olcum; Nevin Ersoy; Alper Bagriyanik; Kursad Genc; Sermin Genc
Journal:  Front Immunol       Date:  2019-07-02       Impact factor: 7.561

Review 10.  Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation.

Authors:  Dora Brites; Adelaide Fernandes
Journal:  Front Cell Neurosci       Date:  2015-12-17       Impact factor: 5.505
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  1 in total

1.  Pinocembrin Inhibits P2X4 Receptor-Mediated Pyroptosis in Hippocampus to Alleviate the Behaviours of Chronic Pain and Depression Comorbidity in Rats.

Authors:  Runan Yang; Jingjian Yang; Zijing Li; Ruichen Su; Lifang Zou; Lin Li; Xiumei Xu; Guilin Li; Shuangmei Liu; Shangdong Liang; Changshui Xu
Journal:  Mol Neurobiol       Date:  2022-09-10       Impact factor: 5.682
  1 in total

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