Rosa Maria Paragliola1, Andrea Corsello2, Eliana Troiani3, Pietro Locantore1, Giampaolo Papi1, Giulia Donnini1, Alfredo Pontecorvi1, Salvatore Maria Corsello1, Cinzia Carrozza3. 1. Unit of Endocrinology, Università Cattolica del Sacro Cuore, Fondazione Policlinico "Gemelli" IRCCS, Largo A. Gemelli 8, 00168, Rome, Italy. 2. Unit of Endocrinology, Università Cattolica del Sacro Cuore, Fondazione Policlinico "Gemelli" IRCCS, Largo A. Gemelli 8, 00168, Rome, Italy. andreacorsello92@gmail.com. 3. Unit of Chemistry, Biochemistry and Clinical Molecular Biology, Università Cattolica del Sacro Cuore, Fondazione Policlinico "Gemelli" IRCCS, Largo A. Gemelli 8, 00168, Rome, Italy.
Abstract
PURPOSE: The activity of the hypothalamus-pituitary-adrenal axis plays a crucial role as an endogenous stress-reactive system. Lifestyle and work often interfere with the endogenous circadian rhythms and can modify the physiological patterns of stress-hormones secretion, including cortisol. We evaluated the cortisol circadian rhythm in the "jet-lag syndrome" that is the most known condition associated with the desynchronization of the circadian rhythm. METHODS: To assess the modifications of cortisol secretion after a long-haul flight, we compared baseline and post-travel salivary cortisol rhythm in a group of 28 healthy eastward travelers (from the U.S.A. or Canada to Italy). The salivary samples were collected about 1 week before the departure at 11 p.m. on day 0 and at 8 a.m., 12 a.m. (midday) and 11 p.m. on day 1 (R0). The same samples were obtained after the landing, the day they flew back home (R1). RESULTS: Statistical analysis showed a significant difference between R0 and R1 for each sample considered (p < 0.005). In particular, the post-travel salivary cortisol levels detected at 11 p.m. both on day 0 and on day 1, were significantly higher than at baseline. Post-travel morning salivary cortisol levels were lower compared with basal rhythm and increased during the morning, reaching the acrophase at 12 a.m. CONCLUSIONS: In eastward travelers, crossing more than five time zones, the cortisol circadian rhythm after the return to the East "remained behind," being synchronized with the West time. This impaired cortisol secretion can contribute to the pathogenesis of the jet-lag syndrome.
PURPOSE: The activity of the hypothalamus-pituitary-adrenal axis plays a crucial role as an endogenous stress-reactive system. Lifestyle and work often interfere with the endogenous circadian rhythms and can modify the physiological patterns of stress-hormones secretion, including cortisol. We evaluated the cortisol circadian rhythm in the "jet-lag syndrome" that is the most known condition associated with the desynchronization of the circadian rhythm. METHODS: To assess the modifications of cortisol secretion after a long-haul flight, we compared baseline and post-travel salivary cortisol rhythm in a group of 28 healthy eastward travelers (from the U.S.A. or Canada to Italy). The salivary samples were collected about 1 week before the departure at 11 p.m. on day 0 and at 8 a.m., 12 a.m. (midday) and 11 p.m. on day 1 (R0). The same samples were obtained after the landing, the day they flew back home (R1). RESULTS: Statistical analysis showed a significant difference between R0 and R1 for each sample considered (p < 0.005). In particular, the post-travel salivary cortisol levels detected at 11 p.m. both on day 0 and on day 1, were significantly higher than at baseline. Post-travel morning salivary cortisol levels were lower compared with basal rhythm and increased during the morning, reaching the acrophase at 12 a.m. CONCLUSIONS: In eastward travelers, crossing more than five time zones, the cortisol circadian rhythm after the return to the East "remained behind," being synchronized with the West time. This impaired cortisol secretion can contribute to the pathogenesis of the jet-lag syndrome.
Authors: Cinzia Carrozza; Salvatore Maria Corsello; Rosa Maria Paragliola; Francesca Ingraudo; Sara Palumbo; Pietro Locantore; Antonella Sferrazza; Alfredo Pontecorvi; Cecilia Zuppi Journal: Ann Clin Biochem Date: 2010-04-20 Impact factor: 2.057
Authors: Paulo Kofuji; Ludovic S Mure; Logan J Massman; Nicole Purrier; Satchidananda Panda; William C Engeland Journal: PLoS One Date: 2016-12-16 Impact factor: 3.240
Authors: Pietro Locantore; Rosa Maria Paragliola; Gianluca Cera; Roberto Novizio; Ettore Maggio; Vittoria Ramunno; Andrea Corsello; Salvatore Maria Corsello Journal: Int J Mol Sci Date: 2022-06-19 Impact factor: 6.208