Mingbo Tang1, Xinliang Gao1, He Sun1, Suyan Tian2, Junxue Dong3, Zhao Liu1, Wei Liu1. 1. Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun 130021, Jilin, China. 2. Department of Division of Clinical Research, The First Hospital of Jilin University, Changchun 130021, Jilin, China. 3. Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin 10117, Germany.
Abstract
OBJECTIVE: To research the impact of neutrophil-lymphocyte ratio (NLR) as a prognostic parameter in non-small-cell lung cancer (NSCLC) patients treated with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). METHODS: We searched the databases such as the American Society of Clinical Oncology (ASCO), EMBASE, PubMed, the European Society of Medical Oncology (ESMO), Wanfang, and CNKI for articles illustrating the impact of pretreatment NLR on survival data in NSCLC patients undergoing EGFR-TKIs treatment. We did a meta-analysis for overall survival (OS) and progression-free survival (PFS). RESULTS: We recruited 10 studies in our meta-analysis. Our study suggested that patients with low NLR had better PFS (hazard ratio (HR) = 1.67, 95% confidence interval (CI) = (1.16-2.39), and P value = 0.005) and OS (HR = 1.66, 95% CI = (1.08-2.55), and P value = 0.02) in comparison to patients with high NLR. CONCLUSION: In conclusion, our meta-analysis revealed that lower NLR predicted a better survival (PFS and OS) in patients receiving the treatment of EGFR-TKIs.
OBJECTIVE: To research the impact of neutrophil-lymphocyte ratio (NLR) as a prognostic parameter in non-small-cell lung cancer (NSCLC) patients treated with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). METHODS: We searched the databases such as the American Society of Clinical Oncology (ASCO), EMBASE, PubMed, the European Society of Medical Oncology (ESMO), Wanfang, and CNKI for articles illustrating the impact of pretreatment NLR on survival data in NSCLC patients undergoing EGFR-TKIs treatment. We did a meta-analysis for overall survival (OS) and progression-free survival (PFS). RESULTS: We recruited 10 studies in our meta-analysis. Our study suggested that patients with low NLR had better PFS (hazard ratio (HR) = 1.67, 95% confidence interval (CI) = (1.16-2.39), and P value = 0.005) and OS (HR = 1.66, 95% CI = (1.08-2.55), and P value = 0.02) in comparison to patients with high NLR. CONCLUSION: In conclusion, our meta-analysis revealed that lower NLR predicted a better survival (PFS and OS) in patients receiving the treatment of EGFR-TKIs.
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