Literature DB >> 33542262

Nasopharyngeal SARS-CoV-2 viral loads in young children do not differ significantly from those in older children and adults.

Sharline Madera1, Emily Crawford2,3,4, Charles Langelier5,2, Nam K Tran6, Ed Thornborrow7, Steve Miller7, Joseph L DeRisi2,4.   

Abstract

The role of children in the spread of the SARS-CoV-2 coronavirus has become a matter of urgent debate as societies in the US and abroad consider how to safely reopen schools. Small studies have suggested higher viral loads in young children. Here we present a multicenter investigation on over five thousand SARS-CoV-2 cases confirmed by real-time reverse transcription (RT) PCR assay. Notably, we found no discernable difference in amount of viral nucleic acid among young children and adults.

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Year:  2021        PMID： 33542262      PMCID： PMC7862672          DOI： 10.1038/s41598-021-81934-w

Source DB:  PubMed          Journal:  Sci Rep        ISSN： 2045-2322            Impact factor:   4.379


  7 in total

1.  Temporal dynamics in viral shedding and transmissibility of COVID-19.

Authors:  Xi He; Eric H Y Lau; Peng Wu; Xilong Deng; Jian Wang; Xinxin Hao; Yiu Chung Lau; Jessica Y Wong; Yujuan Guan; Xinghua Tan; Xiaoneng Mo; Yanqing Chen; Baolin Liao; Weilie Chen; Fengyu Hu; Qing Zhang; Mingqiu Zhong; Yanrong Wu; Lingzhai Zhao; Fuchun Zhang; Benjamin J Cowling; Fang Li; Gabriel M Leung
Journal:  Nat Med       Date:  2020-04-15       Impact factor: 53.440

2.  How do children spread the coronavirus? The science still isn't clear.

Authors:  Smriti Mallapaty
Journal:  Nature       Date:  2020-05       Impact factor: 49.962

3.  Age-Related Differences in Nasopharyngeal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Levels in Patients With Mild to Moderate Coronavirus Disease 2019 (COVID-19).

Authors:  Taylor Heald-Sargent; William J Muller; Xiaotian Zheng; Jason Rippe; Ami B Patel; Larry K Kociolek
Journal:  JAMA Pediatr       Date:  2020-09-01       Impact factor: 16.193

Review 4.  Role of children in the transmission of the COVID-19 pandemic: a rapid scoping review.

Authors:  Luis Rajmil
Journal:  BMJ Paediatr Open       Date:  2020-06-21

5.  Community Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 Disproportionately Affects the Latinx Population During Shelter-in-Place in San Francisco.

Authors:  Gabriel Chamie; Carina Marquez; Emily Crawford; James Peng; Maya Petersen; Daniel Schwab; Joshua Schwab; Jackie Martinez; Diane Jones; Douglas Black; Monica Gandhi; Andrew D Kerkhoff; Vivek Jain; Francesco Sergi; Jon Jacobo; Susana Rojas; Valerie Tulier-Laiwa; Tracy Gallardo-Brown; Ayesha Appa; Charles Chiu; Mary Rodgers; John Hackett; Amy Kistler; Samantha Hao; Jack Kamm; David Dynerman; Joshua Batson; Bryan Greenhouse; Joe DeRisi; Diane V Havlir
Journal:  Clin Infect Dis       Date:  2021-07-30       Impact factor: 9.079

6.  COVID-19 in 7780 pediatric patients: A systematic review.

Authors:  Ansel Hoang; Kevin Chorath; Axel Moreira; Mary Evans; Finn Burmeister-Morton; Fiona Burmeister; Rija Naqvi; Matthew Petershack; Alvaro Moreira
Journal:  EClinicalMedicine       Date:  2020-06-26

7.  Viral dynamics in mild and severe cases of COVID-19.

Authors:  Yang Liu; Li-Meng Yan; Lagen Wan; Tian-Xin Xiang; Aiping Le; Jia-Ming Liu; Malik Peiris; Leo L M Poon; Wei Zhang
Journal:  Lancet Infect Dis       Date:  2020-03-19       Impact factor: 25.071
  7 in total
  16 in total

Review 1.  Rapid, point-of-care antigen tests for diagnosis of SARS-CoV-2 infection.

Authors:  Jacqueline Dinnes; Pawana Sharma; Sarah Berhane; Susanna S van Wyk; Nicholas Nyaaba; Julie Domen; Melissa Taylor; Jane Cunningham; Clare Davenport; Sabine Dittrich; Devy Emperador; Lotty Hooft; Mariska Mg Leeflang; Matthew Df McInnes; René Spijker; Jan Y Verbakel; Yemisi Takwoingi; Sian Taylor-Phillips; Ann Van den Bruel; Jonathan J Deeks
Journal:  Cochrane Database Syst Rev       Date:  2022-07-22

2.  Virologic Features of Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Children.

Authors:  Lael M Yonker; Julie Boucau; James Regan; Manish C Choudhary; Madeleine D Burns; Nicola Young; Eva J Farkas; Jameson P Davis; Peter P Moschovis; T Bernard Kinane; Alessio Fasano; Anne M Neilan; Jonathan Z Li; Amy K Barczak
Journal:  J Infect Dis       Date:  2021-12-01       Impact factor: 7.759

Review 3.  Immunology of SARS-CoV-2 infection in children.

Authors:  Janet Chou; Paul G Thomas; Adrienne G Randolph
Journal:  Nat Immunol       Date:  2022-02-01       Impact factor: 31.250

4.  Lessons learnt during the COVID-19 pandemic: Why Australian schools should be prioritised to stay open.

Authors:  Archana Koirala; Sharon Goldfeld; Asha C Bowen; Catherine Choong; Kathleen Ryan; Nicholas Wood; Noni Winkler; Margie Danchin; Kristine Macartney; Fiona M Russell
Journal:  J Paediatr Child Health       Date:  2021-06-08       Impact factor: 1.929

5.  Viral load and rebound in children with coronavirus disease 2019 during the first outbreak in Daegu city.

Authors:  Mi Ae Chu; Yoon Young Jang; Dong Won Lee; Sung Hoon Kim; Namhee Ryoo; Sunggyun Park; Jae Hee Lee; Hai Lee Chung
Journal:  Clin Exp Pediatr       Date:  2021-10-12

6.  Upper airway gene expression reveals a more robust innate and adaptive immune response to SARS-CoV-2 in children compared with older adults.

Authors:  Eran Mick; Alexandra Tsitsiklis; Natasha Spottiswoode; Saharai Caldera; Paula Serpa; Angela Detweiler; Norma Neff; Angela Oliveira Pisco; Lucy Li; Hanna Retallack; Kalani Ratnasiri; Kayla Williamson; Victoria Soesanto; Eric Simões; A Kistler; Brandie Wagner; Joseph DeRisi; Lilliam Ambroggio; Peter Mourani; Charles Langelier
Journal:  Res Sq       Date:  2021-08-26

7.  Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study.

Authors:  Anika Singanayagam; Seran Hakki; Jake Dunning; Kieran J Madon; Michael A Crone; Aleksandra Koycheva; Nieves Derqui-Fernandez; Jack L Barnett; Michael G Whitfield; Robert Varro; Andre Charlett; Rhia Kundu; Joe Fenn; Jessica Cutajar; Valerie Quinn; Emily Conibear; Wendy Barclay; Paul S Freemont; Graham P Taylor; Shazaad Ahmad; Maria Zambon; Neil M Ferguson; Ajit Lalvani
Journal:  Lancet Infect Dis       Date:  2021-10-29       Impact factor: 25.071

Review 8.  [What role do children in school and kindergarten settings play in transmitting SARS-CoV-2? An evidence-based perspective].

Authors:  Anna Kern; Jessica Diebenbusch; Reinhard Berner; Ingeborg Krägeloh-Mann; Freia De Bock; Herbert Renz-Polster; Johannes Hübner
Journal:  Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz       Date:  2021-11-18       Impact factor: 1.595

9.  The SARS-CoV-2 pandemic in Germany may represent the sum of a large number of local but independent epidemics each initiated by individuals aged 10-19 years, middle-aged males, or elderly individuals.

Authors:  Martin Häusler; Michael Kleines
Journal:  J Med Virol       Date:  2022-03-10       Impact factor: 20.693

10.  Comparison of Symptoms and RNA Levels in Children and Adults With SARS-CoV-2 Infection in the Community Setting.

Authors:  Erin Chung; Eric J Chow; Naomi C Wilcox; Roy Burstein; Elisabeth Brandstetter; Peter D Han; Kairsten Fay; Brian Pfau; Amanda Adler; Kirsten Lacombe; Christina M Lockwood; Timothy M Uyeki; Jay Shendure; Jeffrey S Duchin; Mark J Rieder; Deborah A Nickerson; Michael Boeckh; Michael Famulare; James P Hughes; Lea M Starita; Trevor Bedford; Janet A Englund; Helen Y Chu
Journal:  JAMA Pediatr       Date:  2021-10-04       Impact factor: 26.796
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