| Literature DB >> 33542211 |
Xiaoxiong Wang1,2, Heping Wang3, Jiajun Xu1,2, Xu Hou1,2, Haoqiang Zhan4, Yunbo Zhen5,6.
Abstract
High-grade glioma is the most common and aggressive primary brain tumor in adults with poor therapeutic efficiency and survival prognosis. Cell division cycle associated 8 (CDCA8) has been well known as a cell cycle regulator and tumor promotor in various malignant tumors. However, its biological role in glioma still remains unclear. Our results showed that high level of CDCA8 was significantly correlated with advanced WHO grade and poor overall survival and disease-free survival prognosis. In vitro and in vivo investigations demonstrated that CDCA8 promoted the glioma malignancy by promoting cell proliferation, cell migration, and inhibiting cell apoptosis. Moreover, we found its synergetic biological protein-E2F1 by the gene microarray chip. In this study, we revealed that CDCA8 synergized with E2F1 facilitated the proliferation and migration of glioma. In conclusion, our study provides a novel promising therapeutic targets and prognostic biomarkers for malignant glioma treatment.Entities:
Year: 2021 PMID： 33542211 PMCID： PMC7862266 DOI： 10.1038/s41419-021-03405-4
Source DB: PubMed Journal: Cell Death Dis Impact factor: 8.469