| Literature DB >> 3353726 |
C S Chang1, J Kokontis, S T Liao.
Abstract
Complementary DNAs (cDNAs) encoding androgen receptors were obtained from human testis and rat ventral prostate cDNA libraries. The amino acid sequence deduced from the nucleotide sequences of the cDNAs indicated the presence of a cysteine-rich DNA-binding domain that is highly conserved in all steroid receptors. The human cDNA was transcribed and the RNA product was translated in cell-free systems to yield a 76-kilodalton protein. The protein was immunoprecipitable by human autoimmune antibodies to the androgen receptor. The protein bound androgens specifically and with high affinity.Entities:
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Year: 1988 PMID： 3353726 DOI： 10.1126/science.3353726
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728