| Literature DB >> 33536424 |
Yong-Fei Wang1, Yan Zhang2, Zhiming Lin3, Huoru Zhang1, Ting-You Wang1,4, Yujie Cao1, David L Morris5, Yujun Sheng6, Xianyong Yin6, Shi-Long Zhong7, Xiaoqiong Gu8, Yao Lei1, Jing He2, Qi Wu2, Jiangshan Jane Shen1, Jing Yang1, Tai-Hing Lam9, Jia-Huang Lin9, Zhi-Ming Mai9,10, Mengbiao Guo1, Yuanjia Tang11, Yanhui Chen12, Qin Song13, Bo Ban14, Chi Chiu Mok15, Yong Cui16, Liangjing Lu11, Nan Shen11, Pak C Sham17, Chak Sing Lau18, David K Smith9, Timothy J Vyse5, Xuejun Zhang6, Yu Lung Lau19, Wanling Yang20,21.
Abstract
Systemic lupus erythematosus (SLE), a worldwide autoimmune disease with high heritability, shows differences in prevalence, severity and age of onset among different ancestral groups. Previous genetic studies have focused more on European populations, which appear to be the least affected. Consequently, the genetic variations that underlie the commonalities, differences and treatment options in SLE among ancestral groups have not been well elucidated. To address this, we undertake a genome-wide association study, increasing the sample size of Chinese populations to the level of existing European studies. Thirty-eight novel SLE-associated loci and incomplete sharing of genetic architecture are identified. In addition to the human leukocyte antigen (HLA) region, nine disease loci show clear ancestral differences and implicate antibody production as a potential mechanism for differences in disease manifestation. Polygenic risk scores perform significantly better when trained on ancestry-matched data sets. These analyses help to reveal the genetic basis for disparities in SLE among ancestral groups.Entities:
Year: 2021 PMID： 33536424 DOI： 10.1038/s41467-021-21049-y
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919