James B Wetmore1, Yi Peng2, Heng Yan2, Suying Li2, Muna Irfan2, Andrew Shim2, Nicholas S Roetker2, Victor Abler2, Nazia Rashid2, David T Gilbertson2. 1. From the Chronic Disease Research Group (J.B.W., Y.P., H.Y., S.L., N.S.R., D.T.G.), Hennepin Healthcare Research Institute; Departments of Medicine (J.B.W.) and Neurology (M.I.), Hennepin Healthcare, Minneapolis, MN; ACADIA Pharmaceuticals Inc. (A.S., V.A., N.R.), San Diego; and School of Pharmacy and Applied Sciences (N.R.), Keck Graduate Institute, Claremont, CA. James.Wetmore@hcmed.org. 2. From the Chronic Disease Research Group (J.B.W., Y.P., H.Y., S.L., N.S.R., D.T.G.), Hennepin Healthcare Research Institute; Departments of Medicine (J.B.W.) and Neurology (M.I.), Hennepin Healthcare, Minneapolis, MN; ACADIA Pharmaceuticals Inc. (A.S., V.A., N.R.), San Diego; and School of Pharmacy and Applied Sciences (N.R.), Keck Graduate Institute, Claremont, CA.
Abstract
OBJECTIVE: To determine the association of dementia-related psychosis (DRP) with death and use of long-term care (LTC); we hypothesized that DRP would be associated with increased risk of death and use of LTC in patients with dementia. METHODS: A retrospective cohort study was performed. Medicare claims from 2008 to 2016 were used to define cohorts of patients with dementia and DRP. Outcomes were LTC, defined as nursing home stays of >100 consecutive days, and death. Patients with DRP were directly matched to patients with dementia without psychosis by age, sex, race, number of comorbid conditions, and dementia index year. Association of DRP with outcomes was evaluated using a Cox proportional hazard regression model. RESULTS: We identified 256,408 patients with dementia. Within 2 years after the dementia index date, 13.9% of patients developed DRP and 31.9% had died. Corresponding estimates at 5 years were 25.5% and 64.0%. Mean age differed little between those who developed DRP (83.8 ± 7.9 years) and those who did not (83.1 ± 8.7 years). Patients with DRP were slightly more likely to be female (71.0% vs 68.3%) and white (85.7% vs 82.0%). Within 2 years of developing DRP, 16.1% entered LTC and 52.0% died; corresponding percentages for patients without DRP were 8.4% and 30.0%, respectively. In the matched cohort, DRP was associated with greater risk of LTC (hazard ratio [HR] 2.36, 2.29-2.44) and death (HR 2.06, 2.02-2.10). CONCLUSIONS: DRP was associated with a more than doubling in the risk of death and a nearly 2.5-fold increase in risk of the need for LTC.
OBJECTIVE: To determine the association of dementia-related psychosis (DRP) with death and use of long-term care (LTC); we hypothesized that DRP would be associated with increased risk of death and use of LTC in patients with dementia. METHODS: A retrospective cohort study was performed. Medicare claims from 2008 to 2016 were used to define cohorts of patients with dementia and DRP. Outcomes were LTC, defined as nursing home stays of >100 consecutive days, and death. Patients with DRP were directly matched to patients with dementia without psychosis by age, sex, race, number of comorbid conditions, and dementia index year. Association of DRP with outcomes was evaluated using a Cox proportional hazard regression model. RESULTS: We identified 256,408 patients with dementia. Within 2 years after the dementia index date, 13.9% of patients developed DRP and 31.9% had died. Corresponding estimates at 5 years were 25.5% and 64.0%. Mean age differed little between those who developed DRP (83.8 ± 7.9 years) and those who did not (83.1 ± 8.7 years). Patients with DRP were slightly more likely to be female (71.0% vs 68.3%) and white (85.7% vs 82.0%). Within 2 years of developing DRP, 16.1% entered LTC and 52.0% died; corresponding percentages for patients without DRP were 8.4% and 30.0%, respectively. In the matched cohort, DRP was associated with greater risk of LTC (hazard ratio [HR] 2.36, 2.29-2.44) and death (HR 2.06, 2.02-2.10). CONCLUSIONS:DRP was associated with a more than doubling in the risk of death and a nearly 2.5-fold increase in risk of the need for LTC.
Authors: Joan Forns; Heather E Danysh; Lisa J McQuay; Mary Ellen Turner; Colleen Dempsey; Mary S Anthony; George Demos; J Bradley Layton Journal: BMC Geriatr Date: 2022-10-06 Impact factor: 4.070