Literature DB >> 33536086

Potential therapeutic targets shared between leishmaniasis and cancer.

Sajad Rashidi1, Celia Fernández-Rubio2, Raúl Manzano-Román3, Reza Mansouri4, Reza Shafiei5, Mohammad Ali-Hassanzadeh6, Afshin Barazesh7, Mohammadreza Karimazar1, Gholamreza Hatam8, Paul Nguewa2.   

Abstract

The association of leishmaniasis and malignancies in human and animal models has been highlighted in recent years. The misdiagnosis of coexistence of leishmaniasis and cancer and the use of common drugs in the treatment of such diseases prompt us to further survey the molecular biology of Leishmania parasites and cancer cells. The information regarding common expressed proteins, as possible therapeutic targets, in Leishmania parasites and cancer cells is scarce. Therefore, the current study reviews proteins, and investigates the regulation and functions of several key proteins in Leishmania parasites and cancer cells. The up- and down-regulations of such proteins were mostly related to survival, development, pathogenicity, metabolic pathways and vital signalling in Leishmania parasites and cancer cells. The presence of common expressed proteins in Leishmania parasites and cancer cells reveals valuable information regarding the possible shared mechanisms of pathogenicity and opportunities for therapeutic targeting in leishmaniasis and cancers in the future.

Entities:  

Keywords:  Cancer; Leishmaniasis; common protein; drug; therapeutic target

Year:  2021        PMID： 33536086     DOI： 10.1017/S0031182021000160

Source DB:  PubMed          Journal:  Parasitology        ISSN： 0031-1820            Impact factor:   3.234


  6 in total

Review 1.  The Possible Role of Selected Vitamins and Minerals in the Therapeutic Outcomes of Leishmaniasis.

Authors:  V Udaya Kumar; Muhammed Favas Kt; Ayush Sharma; Priya Bisht; Sameer Dhingra; V Ravichandiran; M Ramesh; Krishna Murti
Journal:  Biol Trace Elem Res       Date:  2022-07-02       Impact factor: 3.738

2.  Effects of negative air ions (NAIs) on Leishmania major: A novel tool for treatment of zoonotic cutaneous leishmaniasis (ZCL).

Authors:  Alireza Badirzadeh; Mehdi Najm; Andrew Hemphill; Maryam Alipour; Hamid Hasanpour; Leila Masoori; Poorya Karimi
Journal:  PLoS One       Date:  2022-09-08       Impact factor: 3.752

3.  Synthesis, Leishmanicidal, Trypanocidal, Antiproliferative Assay and Apoptotic Induction of (2-Phenoxypyridin-3-yl)naphthalene-1(2H)-one Derivatives.

Authors:  Zuleima Blanco; Esteban Fernandez-Moreira; Michael R Mijares; Carmen Celis; Gricelis Martínez; Juan B De Sanctis; Soňa Gurská; Petr Džubák; Marián Hajdůch; Ali Mijoba; Yael García; Xenón Serrano; Nahum Herrera; Jhonny Correa-Abril; Yonathan Parra; Jorge Ángel; Hegira Ramírez; Jaime E Charris
Journal:  Molecules       Date:  2022-08-31       Impact factor: 4.927

4.  Exploring novel nitrofuranyl sulfonohydrazides as anti-Leishmania and anti-cancer agents: Synthesis, in vitro efficacy and hit identification.

Authors:  Christina Kannigadu; Janine Aucamp; David D N'Da
Journal:  Chem Biol Drug Des       Date:  2022-06-21       Impact factor: 2.873

5.  In Silico Characterization of Calcineurin from Pathogenic Obligate Intracellular Trypanosomatids: Potential New Biological Roles.

Authors:  Patricio R Orrego; Mayela Serrano-Rodríguez; Mauro Cortez; Jorge E Araya
Journal:  Biomolecules       Date:  2021-09-07

Review 6.  Tricyclodecan-9-yl-Xanthogenate (D609): Mechanism of Action and Pharmacological Applications.

Authors:  Aashiq Hussain Bhat; Khalid Bashir Dar; Andleeb Khan; Saeed Alshahrani; Sultan M Alshehri; Mohammed M Ghoneim; Prawez Alam; Faiyaz Shakeel
Journal:  Int J Mol Sci       Date:  2022-03-18       Impact factor: 5.923
  6 in total

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