Felipe V C Machado1,2,3,4, Roy Meys5,6,7, Jeannet M Delbressine5, Anouk W Vaes5, Yvonne M J Goërtz5,6,7, Maarten van Herck5,6,7,8, Sarah Houben-Wilke5, Gudula J A M Boon9, Stefano Barco10,11, Chris Burtin8, Alex van 't Hul12, Rein Posthuma5,6,7, Frits M E Franssen5,6,7, Yvonne Spies13, Herman Vijlbrief13, Fabio Pitta14, Spencer A Rezek15, Daisy J A Janssen5,16, Bob Siegerink17,18, Frederikus A Klok9,10, Martijn A Spruit5,6,7,8. 1. Department of Research and Development, CIRO+, PO Box 4080, 6080 AB, Horn, Haelen, The Netherlands. felipemachado@ciro-horn.nl. 2. NUTRIM School of Nutrition and Translational Research in Metabolism, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands. felipemachado@ciro-horn.nl. 3. Department of Respiratory Medicine, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands. felipemachado@ciro-horn.nl. 4. Laboratory of Research in Respiratory Physiotherapy (LFIP), Department of Physiotherapy, State University of Londrina (UEL), Londrina, Brazil. felipemachado@ciro-horn.nl. 5. Department of Research and Development, CIRO+, PO Box 4080, 6080 AB, Horn, Haelen, The Netherlands. 6. NUTRIM School of Nutrition and Translational Research in Metabolism, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands. 7. Department of Respiratory Medicine, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands. 8. REVAL Rehabilitation Research Center, BIOMED Biomedical Research Institute, Faculty of Rehabilitation Sciences, Hasselt University, Diepenbeek, Belgium. 9. Department of Medicine - Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands. 10. Center for Thrombosis and Haemostasis (CTH), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany. 11. Clinic of Angiology, University Hospital Zurich, Zurich, Switzerland. 12. Department of Respiratory Diseases, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands. 13. Lung Foundation Netherlands, Amersfoort, The Netherlands. 14. Laboratory of Research in Respiratory Physiotherapy (LFIP), Department of Physiotherapy, State University of Londrina (UEL), Londrina, Brazil. 15. Institute of Therapies and Rehabilitation, Kantonsspital Winterthur, Winterthur, Switzerland. 16. Department of Health Services Research, Care and Public Health Research Institute, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands. 17. Center for Stroke Research Berlin, Charité Universitätsmedizin Berlin, Berlin, Germany. 18. Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Abstract
BACKGROUND: An increasing number of subjects are recovering from COVID-19, raising the need for tools to adequately assess the course of the disease and its impact on functional status. We aimed to assess the construct validity of the Post-COVID-19 Functional Status (PCFS) Scale among adult subjects with confirmed and presumed COVID-19. METHODS: Adult subjects with confirmed and presumed COVID-19, who were members of an online panel and two Facebook groups for subjects with COVID-19 with persistent symptoms, completed an online survey after the onset of infection-related symptoms. The number and intensity of symptoms were evaluated with the Utrecht Symptom Diary, health-related quality of life (HrQoL) with the 5-level EQ-5D questionnaire, impairment in work and activities with the Work Productivity and Activity Impairment questionnaire and functional status with the PCFS Scale. RESULTS: 1939 subjects were included in the analyses (85% women, 95% non-hospitalized during infection) about 3 months after the onset of infection-related symptoms. Subjects classified as experiencing 'slight', 'moderate' and 'severe' functional limitations presented a gradual increase in the number/intensity of symptoms, reduction of HrQoL and impairment in work and usual activities. No differences were found regarding the number and intensity of symptoms, HrQoL and impairment in work and usual activities between subjects classified as experiencing 'negligible' and 'no' functional limitations. We found weak-to-strong statistical associations between functional status and all domains of HrQoL (r: 0.233-0.661). Notably, the strongest association found was with the 'usual activities' domain of the 5-level EQ-5D questionnaire. CONCLUSION: We demonstrated the construct validity of the PCFS Scale in highly-symptomatic adult subjects with confirmed and presumed COVID-19, 3 months after the onset of symptoms.
BACKGROUND: An increasing number of subjects are recovering from COVID-19, raising the need for tools to adequately assess the course of the disease and its impact on functional status. We aimed to assess the construct validity of the Post-COVID-19 Functional Status (PCFS) Scale among adult subjects with confirmed and presumed COVID-19. METHODS: Adult subjects with confirmed and presumed COVID-19, who were members of an online panel and two Facebook groups for subjects with COVID-19 with persistent symptoms, completed an online survey after the onset of infection-related symptoms. The number and intensity of symptoms were evaluated with the Utrecht Symptom Diary, health-related quality of life (HrQoL) with the 5-level EQ-5D questionnaire, impairment in work and activities with the Work Productivity and Activity Impairment questionnaire and functional status with the PCFS Scale. RESULTS: 1939 subjects were included in the analyses (85% women, 95% non-hospitalized during infection) about 3 months after the onset of infection-related symptoms. Subjects classified as experiencing 'slight', 'moderate' and 'severe' functional limitations presented a gradual increase in the number/intensity of symptoms, reduction of HrQoL and impairment in work and usual activities. No differences were found regarding the number and intensity of symptoms, HrQoL and impairment in work and usual activities between subjects classified as experiencing 'negligible' and 'no' functional limitations. We found weak-to-strong statistical associations between functional status and all domains of HrQoL (r: 0.233-0.661). Notably, the strongest association found was with the 'usual activities' domain of the 5-level EQ-5D questionnaire. CONCLUSION: We demonstrated the construct validity of the PCFS Scale in highly-symptomatic adult subjects with confirmed and presumed COVID-19, 3 months after the onset of symptoms.
Entities:
Keywords:
Functional status; Quality of life; SARS-CoV-2; Symptoms
Authors: L Costa Leite; L Carvalho; D Marcos de Queiroz; M S Quintino Farias; V Cavalheri; D W Edgar; B Ribeiro do Amaral Nery; N Vasconcelos Barros; V Maldaner; N Gurgel Campos; R Mesquita Journal: Pulmonology Date: 2022-01-12
Authors: Maarten Van Herck; Yvonne M J Goërtz; Sarah Houben-Wilke; Felipe V C Machado; Roy Meys; Jeannet M Delbressine; Anouk W Vaes; Chris Burtin; Rein Posthuma; Frits M E Franssen; Bita Hajian; Herman Vijlbrief; Yvonne Spies; Alex J van 't Hul; Daisy J A Janssen; Martijn A Spruit Journal: J Med Internet Res Date: 2021-09-21 Impact factor: 5.428
Authors: Anouk W Vaes; Yvonne M J Goërtz; Maarten Van Herck; Felipe V C Machado; Roy Meys; Jeannet M Delbressine; Sarah Houben-Wilke; Swetlana Gaffron; Dieter Maier; Chris Burtin; Rein Posthuma; Nicole P H van Loon; Frits M E Franssen; Bita Hajian; Sami O Simons; Job F M van Boven; Frederikus A Klok; Bart Spaetgens; Claire M H Pinxt; Limmie Y L Liu; Geertjan Wesseling; Yvonne Spies; Herman Vijlbrief; Alex J van 't Hul; Daisy J A Janssen; Martijn A Spruit Journal: ERJ Open Res Date: 2021-05-24