Yu Zhang1,2, Huiwen Tan1, Jingjing Tang3, Jing Li1, Weelic Chong4, Yang Hai5, Yuning Feng2, L Dade Lunsford6, Ping Xu7, Desheng Jia1, Fang Fang8. 1. West China Hospital, Sichuan University, Chengdu, Sichuan, China. 2. Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China. 3. Chinese University of Hong Kong, Shenzhen, Guangdong, China. 4. Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA. 5. Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA. 6. University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA. 7. Sichuan University Library, Sichuan University, Chengdu, Sichuan, China. 8. West China Hospital, Sichuan University, Chengdu, Sichuan, China fangfang1057@outlook.com.
Abstract
BACKGROUND: While observational studies have shown an association between vitamin D insufficiency and diabetes, it is unclear whether intervention with vitamin D supplements can lower the risk of type 2 diabetes mellitus (T2DM). PURPOSE: To assess whether vitamin D supplementation reduces the risk of T2DM in people with prediabetes. DATA SOURCES: We searched MEDLINE, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) from inception to 5 July 2019. STUDY SELECTION: We included randomized controlled trials assessing vitamin D supplementation versus placebo in relation to new-onset T2DM in people with prediabetes. DATA EXTRACTION: We screened studies and extracted data from published trials independently. DATA SYNTHESIS: We identified eight eligible trials with a total of 4,896 subjects. Vitamin D supplementation significantly reduced the risk of T2DM (risk ratio [RR] 0.89 [95% CI 0.80-0.99]; I 2 = 0%). Benefit was found in nonobese subjects (RR 0.73 [95% CI 0.57-0.92]) but not in obese subjects (RR 0.95 [95% CI 0.84-1.08]) (P interaction = 0.048). The reversion of prediabetes to normoglycemia occurred in 116 of 548 (21.2%) participants in the vitamin D group and 75 of 532 (14.1%) in the control group. Vitamin D supplementation increased reversion rate of prediabetes to normoglycemia (RR 1.48 [95% CI 1.14-1.92]; I 2 = 0%.) LIMITATIONS: Definitions of prediabetes and new-onset diabetes in eligible studies were different, and long-term data on outcomes of T2DM prevention were lacking. CONCLUSIONS: In persons with prediabetes, vitamin D supplementation reduces the risk of T2DM and increases the reversion rate of prediabetes to normoglycemia. The benefit of the prevention of T2DM could be limited to nonobese subjects. Individual participant data meta-analyses are needed to confirm these findings.
BACKGROUND: While observational studies have shown an association between vitamin Dinsufficiency and diabetes, it is unclear whether intervention with vitamin D supplements can lower the risk of type 2 diabetes mellitus (T2DM). PURPOSE: To assess whether vitamin D supplementation reduces the risk of T2DM in people with prediabetes. DATA SOURCES: We searched MEDLINE, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) from inception to 5 July 2019. STUDY SELECTION: We included randomized controlled trials assessing vitamin D supplementation versus placebo in relation to new-onset T2DM in people with prediabetes. DATA EXTRACTION: We screened studies and extracted data from published trials independently. DATA SYNTHESIS: We identified eight eligible trials with a total of 4,896 subjects. Vitamin D supplementation significantly reduced the risk of T2DM (risk ratio [RR] 0.89 [95% CI 0.80-0.99]; I 2 = 0%). Benefit was found in nonobese subjects (RR 0.73 [95% CI 0.57-0.92]) but not in obese subjects (RR 0.95 [95% CI 0.84-1.08]) (P interaction = 0.048). The reversion of prediabetes to normoglycemia occurred in 116 of 548 (21.2%) participants in the vitamin D group and 75 of 532 (14.1%) in the control group. Vitamin D supplementation increased reversion rate of prediabetes to normoglycemia (RR 1.48 [95% CI 1.14-1.92]; I 2 = 0%.) LIMITATIONS: Definitions of prediabetes and new-onset diabetes in eligible studies were different, and long-term data on outcomes of T2DM prevention were lacking. CONCLUSIONS: In persons with prediabetes, vitamin D supplementation reduces the risk of T2DM and increases the reversion rate of prediabetes to normoglycemia. The benefit of the prevention of T2DM could be limited to nonobese subjects. Individual participant data meta-analyses are needed to confirm these findings.
Authors: Marni E Shoemaker; Linda M Huynh; Cory M Smith; Vikkie A Mustad; Maria O Duarte; Joel T Cramer Journal: Top Clin Nutr Date: 2022-06-22 Impact factor: 0.441
Authors: Neda Rasouli; Irwin G Brodsky; Ranee Chatterjee; Sun H Kim; Richard E Pratley; Myrlene A Staten; Anastassios G Pittas Journal: J Clin Endocrinol Metab Date: 2022-01-01 Impact factor: 6.134
Authors: Jill Hahn; Nancy R Cook; Erik K Alexander; Sonia Friedman; Joseph Walter; Vadim Bubes; Gregory Kotler; I-Min Lee; JoAnn E Manson; Karen H Costenbader Journal: BMJ Date: 2022-01-26
Authors: Sun H Kim; Irwin G Brodsky; Ranee Chatterjee; Sangeeta R Kashyap; William C Knowler; Emilia Liao; Jason Nelson; Richard Pratley; Neda Rasouli; Ellen M Vickery; Mark Sarnak; Anastassios G Pittas Journal: Clin J Am Soc Nephrol Date: 2021-08 Impact factor: 10.614
Authors: John P Bilezikian; Anna Maria Formenti; Robert A Adler; Neil Binkley; Roger Bouillon; Marise Lazaretti-Castro; Claudio Marcocci; Nicola Napoli; Rene Rizzoli; Andrea Giustina Journal: Rev Endocr Metab Disord Date: 2021-12-23 Impact factor: 6.514