Shumei Li1, Bin A Wang2, Cheng Li3, Ying Feng1,4, Meng Li1, Tianyue Wang1, Linghui Nie3, Changhong Li1, Wen Hua1, Chulan Lin1, Mengchen Liu1, Xiaofen Ma1, Jin Fang1, Guihua Jiang5. 1. Department of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, China. 2. Department of Neurology, BG University Hospital Bergmannsheil, Ruhr-University Bochum, Bochum, Germany. 3. Guangdong Traditional Medical and Sports Injury Rehabilitation Research Institute, Guangdong Second Provincial General Hospital, Guangzhou, China. 4. The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China. 5. Department of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, China. GH.jiang2002@163.com.
Abstract
OBJECTIVE: To investigate the gray matter (GM) alterations in patients with insomnia disorder (ID) at different severity stages and the relationship between GM alterations and sleep, mood, and cognitive measures. METHODS: One hundred one ID patients and 63 healthy controls (HC) were included. Each patient underwent structural MRI and completed sleep-, mood-, and cognitive-related questionnaires. The ID patients were further grouped into subthreshold insomnia (SI) group and clinical insomnia (CI) group. We investigated changes in GM volumes in ID patients via diffeomorphic anatomical registration through exponentiated lie algebra voxel-based morphometry (DARTEL-VBM). We first compared voxel-wise differences in GM volumes between the HC group and the ID group. Analysis of variance was performed on individual GM maps in the SI, CI, and HC groups to further investigate the effects of different stages of ID severity on GM volumes. Multiple regression was used to model the relationship between altered GM volumes in SI and CI groups and clinical measures. RESULTS: GM hypertrophies in the left anterior and middle cingulate gyrus, right middle and inferior temporal gyrus, and right cerebellum Crus II were detected in ID. Increased GM volume in the right middle temporal gyrus was detected in the SI group, whereas all three regions in the CI group. Regression analysis showed that mood- and cognitive-related measures had a positive correlation with GM volumes, while sleep-related measures had a negative correlation with GM volumes in the CI group. CONCLUSIONS: Our findings of the progressively increased GM volumes in ID suggest that a hypertrophic cortical morphological mechanism may underlie the altered neuroanatomy induced by insomnia. KEY POINTS: • Insomnia-induced GM hypertrophies in the cingulate gyrus, temporal gyrus, and cerebellum Crus II. • The middle temporal gyrus was early detectable in the SI group. • The increased GM volumes in the CI group were correlated with clinical measures.
OBJECTIVE: To investigate the gray matter (GM) alterations in patients with insomnia disorder (ID) at different severity stages and the relationship between GM alterations and sleep, mood, and cognitive measures. METHODS: One hundred one ID patients and 63 healthy controls (HC) were included. Each patient underwent structural MRI and completed sleep-, mood-, and cognitive-related questionnaires. The ID patients were further grouped into subthreshold insomnia (SI) group and clinical insomnia (CI) group. We investigated changes in GM volumes in ID patients via diffeomorphic anatomical registration through exponentiated lie algebra voxel-based morphometry (DARTEL-VBM). We first compared voxel-wise differences in GM volumes between the HC group and the ID group. Analysis of variance was performed on individual GM maps in the SI, CI, and HC groups to further investigate the effects of different stages of ID severity on GM volumes. Multiple regression was used to model the relationship between altered GM volumes in SI and CI groups and clinical measures. RESULTS: GM hypertrophies in the left anterior and middle cingulate gyrus, right middle and inferior temporal gyrus, and right cerebellum Crus II were detected in ID. Increased GM volume in the right middle temporal gyrus was detected in the SI group, whereas all three regions in the CI group. Regression analysis showed that mood- and cognitive-related measures had a positive correlation with GM volumes, while sleep-related measures had a negative correlation with GM volumes in the CI group. CONCLUSIONS: Our findings of the progressively increased GM volumes in ID suggest that a hypertrophic cortical morphological mechanism may underlie the altered neuroanatomy induced by insomnia. KEY POINTS: • Insomnia-induced GM hypertrophies in the cingulate gyrus, temporal gyrus, and cerebellum Crus II. • The middle temporal gyrus was early detectable in the SI group. • The increased GM volumes in the CI group were correlated with clinical measures.
Authors: Josine G van Mill; Witte J G Hoogendijk; Nicole Vogelzangs; Richard van Dyck; Brenda W J H Penninx Journal: J Clin Psychiatry Date: 2010-03 Impact factor: 4.384
Authors: Eric A Nofzinger; Daniel J Buysse; Anne Germain; Julie C Price; Jean M Miewald; David J Kupfer Journal: Am J Psychiatry Date: 2004-11 Impact factor: 18.112
Authors: Ravi Gupta; Dora Zalai; David Warren Spence; Ahmed S BaHammam; Chellamuthu Ramasubramanian; Jaime M Monti; Seithikurippu R Pandi-Perumal Journal: Asian J Psychiatr Date: 2014-12
Authors: John W Winkelman; David T Plante; Laura Schoerning; Kathleen Benson; Orfeu M Buxton; Shawn P O'Connor; J Eric Jensen; Perry F Renshaw; Atilla Gonenc Journal: Sleep Date: 2013-07-01 Impact factor: 5.849