Jiyoung Ma1,2, Gahae Hong1, Eunji Ha1,3, Haejin Hong1,3, Jinsol Kim1,3, Yoonji Joo1,4, Sujung Yoon1,3, In Kyoon Lyoo1,3,4,5, Jungyoon Kim6,7. 1. Ewha Brain Institute, Ewha Womans University, Seoul, South Korea. 2. Diagnostic Neuroimaging, University of Utah, Salt Lake City, Utah, USA. 3. Department of Brain and Cognitive Sciences, Ewha Womans University, Seoul, South Korea. 4. Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, South Korea. 5. Department of Psychiatry, University of Utah, Salt Lake City, Utah, USA. 6. Ewha Brain Institute, Ewha Womans University, Seoul, South Korea. jungyoon.kimm@ewha.ac.kr. 7. Department of Brain and Cognitive Sciences, Ewha Womans University, Seoul, South Korea. jungyoon.kimm@ewha.ac.kr.
Abstract
BACKGROUND: Recent evidence suggests that hyperbaric oxygenation (HBO), which has been used as an effective treatment for certain types of tissue injury, may change neural activities in the human brain and subsequently improve symptoms of psychiatric disorders. To scrutinize the neural mechanism of HBO in the human brain, we investigated whether 20 sessions of HBO changed regional cerebral blood flow (rCBF) of the limbic system in firefighters with mild traumatic brain injury (mTBI) and subjective emotional distress. METHODS: Twenty firefighters with mTBI and mild emotional distress were treated with HBO at a relatively low pressure of 1.3 atmospheres absolute for 45 min a day for 20 consecutive days (the mild emotional distress group). The rCBF of the limbic system was measured using an arterial spin labeling perfusion magnetic resonance imaging before and after the HBO. Analyses were performed on the data from fourteen individuals who completed the study and 14 age- and sex-matched healthy firefighters (the comparison group). RESULTS: Firefighters in the mild emotional distress group showed increase rCBF following HBO in a cluster encompassing the right hippocampal and parahippocampal regions (peak t = 4.31; cluster size = 248 mm3)(post-hoc analysis, z = 5.92, p < 0.001) that had lower rCBF relative to the comparison group at baseline (post-hoc analysis, t = -2.20, p = 0.04). CONCLUSION: The current study demonstrated that low-pressure HBO might increase rCBF of the hippocampal and parahippocampal regions, suggesting a potential underpinning mechanism of HBO in the human brain.
BACKGROUND: Recent evidence suggests that hyperbaric oxygenation (HBO), which has been used as an effective treatment for certain types of tissue injury, may change neural activities in the human brain and subsequently improve symptoms of psychiatric disorders. To scrutinize the neural mechanism of HBO in the human brain, we investigated whether 20 sessions of HBO changed regional cerebral blood flow (rCBF) of the limbic system in firefighters with mild traumatic brain injury (mTBI) and subjective emotional distress. METHODS: Twenty firefighters with mTBI and mild emotional distress were treated with HBO at a relatively low pressure of 1.3 atmospheres absolute for 45 min a day for 20 consecutive days (the mild emotional distress group). The rCBF of the limbic system was measured using an arterial spin labeling perfusion magnetic resonance imaging before and after the HBO. Analyses were performed on the data from fourteen individuals who completed the study and 14 age- and sex-matched healthy firefighters (the comparison group). RESULTS: Firefighters in the mild emotional distress group showed increase rCBF following HBO in a cluster encompassing the right hippocampal and parahippocampal regions (peak t = 4.31; cluster size = 248 mm3)(post-hoc analysis, z = 5.92, p < 0.001) that had lower rCBF relative to the comparison group at baseline (post-hoc analysis, t = -2.20, p = 0.04). CONCLUSION: The current study demonstrated that low-pressure HBO might increase rCBF of the hippocampal and parahippocampal regions, suggesting a potential underpinning mechanism of HBO in the human brain.
Authors: R Scott Miller; Lindell K Weaver; Nazanin Bahraini; Susan Churchill; Robert C Price; Virginia Skiba; James Caviness; Scott Mooney; Brian Hetzell; Jun Liu; Kayla Deru; Richard Ricciardi; Susan Fracisco; Nicole C Close; Gerald W Surrett; Corinna Bartos; Margaret Ryan; Lisa A Brenner Journal: JAMA Intern Med Date: 2015-01 Impact factor: 21.873
Authors: Paul G Harch; Susan R Andrews; Edward F Fogarty; Daniel Amen; John C Pezzullo; Juliette Lucarini; Claire Aubrey; Derek V Taylor; Paul K Staab; Keith W Van Meter Journal: J Neurotrauma Date: 2011-11-22 Impact factor: 5.269
Authors: David C Alsop; John A Detre; Xavier Golay; Matthias Günther; Jeroen Hendrikse; Luis Hernandez-Garcia; Hanzhang Lu; Bradley J MacIntosh; Laura M Parkes; Marion Smits; Matthias J P van Osch; Danny J J Wang; Eric C Wong; Greg Zaharchuk Journal: Magn Reson Med Date: 2014-04-08 Impact factor: 4.668