Suyan Tian1, Mingyue Zhang2, Zhiming Ma3. 1. Division of Clinical Research, First Hospital of Jilin University, 1 Xinmin Street, Changchun, 130021, Jilin, People's Republic of China. wmxt@jlu.edu.cn. 2. Department of Gastroenterology, First Hospital of Jilin University, 1 Xinmin Street, Changchun, 130021, Jilin, People's Republic of China. 3. Department of Gastrointestinal Nutrition and Hernia Surgery, Second Hospital of Jilin University, 218 Ziqiang Road, Changchun, 130041, Jilin, People's Republic of China. mazhiming@jlu.edu.cn.
Abstract
BACKGROUND: Colon cancer (CC) is one of the most common malignant tumors, while Parkinson's disease (PD) is the second most common neurodegenerative disorder. Recent accumulating evidence indicates that these two diseases are associated with each other. Also, from the perspective of long non-coding RNAs, some well-known genes such as H19 and PVT1 can link these two diseases together. Several studies have shown that patients with PD had a decreased risk of developing CC compared with patients without PD. However, controversies surround the relationship between PD and CC, and to date, no concordant conclusion has been drawn. METHODS: In this study, we aimed to assess the association between these two diseases based on lncRNA-to-lncRNA interactions. Motivated by the weighted gene co-expression network analysis method, a customized procedure was proposed and used to identify differentially correlated edges (DCEs) in the respective interaction networks for PD and CC and explore how these two diseases are linked. RESULTS: Of the two sets of DCEs for PD and CC, 16 pairs overlapped. Among them, 15 edges had opposite signs, with positive signs for CC indicating a gain of connectivity, whereas negative signs for PD indicating a loss of connectivity. CONCLUSIONS: By using the lncRNA expression profiles, and a customized procedure, an answer to the question about how PD and CC are associated is provided.
BACKGROUND:Colon cancer (CC) is one of the most common malignant tumors, while Parkinson's disease (PD) is the second most common neurodegenerative disorder. Recent accumulating evidence indicates that these two diseases are associated with each other. Also, from the perspective of long non-coding RNAs, some well-known genes such as H19 and PVT1 can link these two diseases together. Several studies have shown that patients with PD had a decreased risk of developing CC compared with patients without PD. However, controversies surround the relationship between PD and CC, and to date, no concordant conclusion has been drawn. METHODS: In this study, we aimed to assess the association between these two diseases based on lncRNA-to-lncRNA interactions. Motivated by the weighted gene co-expression network analysis method, a customized procedure was proposed and used to identify differentially correlated edges (DCEs) in the respective interaction networks for PD and CC and explore how these two diseases are linked. RESULTS: Of the two sets of DCEs for PD and CC, 16 pairs overlapped. Among them, 15 edges had opposite signs, with positive signs for CC indicating a gain of connectivity, whereas negative signs for PD indicating a loss of connectivity. CONCLUSIONS: By using the lncRNA expression profiles, and a customized procedure, an answer to the question about how PD and CC are associated is provided.
Authors: Christopher R Cabanski; Nicole M White; Ha X Dang; Jessica M Silva-Fisher; Corinne E Rauck; Danielle Cicka; Christopher A Maher Journal: RNA Biol Date: 2015 Impact factor: 4.652
Authors: Timothy G Lesnick; Spiridon Papapetropoulos; Deborah C Mash; Jarlath Ffrench-Mullen; Lina Shehadeh; Mariza de Andrade; John R Henley; Walter A Rocca; J Eric Ahlskog; Demetrius M Maraganore Journal: PLoS Genet Date: 2007-06 Impact factor: 5.917