| Literature DB >> 33529682 |
Akshay Bareja1, James A Draper1, Lauren H Katz2, David E Lee1, Paul A Grimsrud3, James P White4.
Abstract
Caloric restriction (CR) can prolong aged skeletal muscle function, yet the molecular mechanisms are not completely understood. We performed phosphoproteomic analysis on muscle from young and old mice fed an ad libitum diet, and old mice fed a CR diet. CR promoted a youthful phosphoproteomic signature, suppressing several known "pro-aging" pathways including Protein kinase A (PKA). This study validates global signaling changes in skeletal muscle during CR.Entities:
Keywords: Aging; Caloric restriction; Mice; PKA; Phosphoproteome
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Year: 2021 PMID: 33529682 PMCID: PMC8035222 DOI: 10.1016/j.mad.2021.111443
Source DB: PubMed Journal: Mech Ageing Dev ISSN: 0047-6374 Impact factor: 5.432