Literature DB >> 33529682

Chronic caloric restriction maintains a youthful phosphoproteome in aged skeletal muscle.

Akshay Bareja1, James A Draper1, Lauren H Katz2, David E Lee1, Paul A Grimsrud3, James P White4.   

Abstract

Caloric restriction (CR) can prolong aged skeletal muscle function, yet the molecular mechanisms are not completely understood. We performed phosphoproteomic analysis on muscle from young and old mice fed an ad libitum diet, and old mice fed a CR diet. CR promoted a youthful phosphoproteomic signature, suppressing several known "pro-aging" pathways including Protein kinase A (PKA). This study validates global signaling changes in skeletal muscle during CR.
Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Aging; Caloric restriction; Mice; PKA; Phosphoproteome

Mesh:

Substances:

Year:  2021        PMID: 33529682      PMCID: PMC8035222          DOI: 10.1016/j.mad.2021.111443

Source DB:  PubMed          Journal:  Mech Ageing Dev        ISSN: 0047-6374            Impact factor:   5.432


  19 in total

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2.  Semi-supervised learning for peptide identification from shotgun proteomics datasets.

Authors:  Lukas Käll; Jesse D Canterbury; Jason Weston; William Stafford Noble; Michael J MacCoss
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3.  Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression.

Authors:  Chia-Wei Cheng; Gregor B Adams; Laura Perin; Min Wei; Xiaoying Zhou; Ben S Lam; Stefano Da Sacco; Mario Mirisola; David I Quinn; Tanya B Dorff; John J Kopchick; Valter D Longo
Journal:  Cell Stem Cell       Date:  2014-06-05       Impact factor: 24.633

4.  Protein kinase A is a target for aging and the aging heart.

Authors:  Linda C Enns; Christina Pettan-Brewer; Warren Ladiges
Journal:  Aging (Albany NY)       Date:  2010-04       Impact factor: 5.682

5.  Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.

Authors:  Gurpreet S Baht; Akshay Bareja; David E Lee; Rajesh R Rao; Rong Huang; Janet L Huebner; David B Bartlett; Corey R Hart; Jason R Gibson; Ian R Lanza; Virginia B Kraus; Simon G Gregory; Bruce M Spiegelman; James P White
Journal:  Nat Metab       Date:  2020-03-16

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Review 7.  Skeletal muscle as an experimental model of choice to study tissue aging and rejuvenation.

Authors:  Jessy Etienne; Chao Liu; Colin M Skinner; Michael J Conboy; Irina M Conboy
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8.  Disruption of protein kinase A in mice enhances healthy aging.

Authors:  Linda C Enns; John F Morton; Piper R Treuting; Mary J Emond; Norman S Wolf; Dao-Fu Dai; G S McKnight; Peter S Rabinovitch; Warren C Ladiges
Journal:  PLoS One       Date:  2009-06-18       Impact factor: 3.240

9.  The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.

Authors:  Phillip J White; Robert W McGarrah; Paul A Grimsrud; Shih-Chia Tso; Wen-Hsuan Yang; Jonathan M Haldeman; Thomas Grenier-Larouche; Jie An; Amanda L Lapworth; Inna Astapova; Sarah A Hannou; Tabitha George; Michelle Arlotto; Lyra B Olson; Michelle Lai; Guo-Fang Zhang; Olga Ilkayeva; Mark A Herman; R Max Wynn; David T Chuang; Christopher B Newgard
Journal:  Cell Metab       Date:  2018-05-17       Impact factor: 31.373

10.  Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9.

Authors:  Min Wei; Paola Fabrizio; Jia Hu; Huanying Ge; Chao Cheng; Lei Li; Valter D Longo
Journal:  PLoS Genet       Date:  2007-12-13       Impact factor: 5.917

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  1 in total

1.  Proteomics and phosphoproteomics datasets of a muscle-specific STIM1 loss-of-function mouse model.

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  1 in total

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