Literature DB >> 33527016

Systematic analysis using a bioinformatics strategy identifies SFTA1P and LINC00519 as potential prognostic biomarkers for lung squamous cell carcinoma.

Yu-Zhen Yin1,2, Shi-Hua Yao3, Chun-Guang Li3, Yu-Shui Ma1,4,5, Zhou-Jun Kang6, Jia-Jia Zhang1, Cheng-You Jia1, Li-Kun Hou7, Shan-Shan Qin1, Xin Fan1, Han Zhang1, Meng-Die Yang1, Dan-Dan Zhang8, Gai-Xia Lu1, Hui-Min Wang8, Li-Peng Gu8, Lin-Lin Tian8, Pei-Yao Wang8, Ping-Sheng Cao8, Wei Wu7, Zi-Yang Cao7, Zhong-Wei Lv1, Bo-Wen Shi3, Chun-Yan Wu7, Geng-Xi Jiang3, Da Fu8, Fei Yu1,2.   

Abstract

Lung cancer has high incidence and mortality rates, in which lung squamous cell carcinoma (LUSC) is a primary type of non-small cell lung carcinoma (NSCLC). The aim of our study was to discover long non-coding RNAs (lncRNAs) associated with diagnose and prognosis for LUSC. RNA sequencing data obtained from LUSC samples were extracted from The Cancer Genome Atlas database (TCGA). Two prognosis-associated lncRNAs (including SFTA1P and LINC00519) were selected from LUSC samples, and the expression levels were also verified to be associated abnormal in LUSC clinical samples. Our findings demonstrate that lncRNAs SFTA1P and LINC00519 exert important functions in human LUSC and may serve as new targets for LUSC diagnosis and therapy. AJTR
Copyright © 2021.

Entities:  

Keywords:  LINC00519; LUSC; SFTA1P; diagnosis; prognosis

Year:  2021        PMID： 33527016      PMCID： PMC7847518     

Source DB:  PubMed          Journal:  Am J Transl Res        ISSN： 1943-8141            Impact factor:   4.060


  79 in total

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