Yingying Cao1, Simo Kitanovski1, Ralf Küppers2, Daniel Hoffmann3. 1. Bioinformatics and Computational Biophysics, Faculty of Biology and Center for Medical Biotechnology, University of Duisburg-Essen, Essen, Germany. 2. Institute of Cell Biology (Cancer Research), University Hospital Essen, Essen, Germany. 3. Bioinformatics and Computational Biophysics, Faculty of Biology and Center for Medical Biotechnology, University of Duisburg-Essen, Essen, Germany. daniel.hoffmann@uni-due.de.