Ryo Terauchi1, Shumpei Ogawa2, Akiko Sotozono2, Takahiko Noro2, Masayuki Tatemichi3, Tadashi Nakano2. 1. Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan. r.terauchi0813@gmail.com. 2. Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan. 3. Department of Preventive Medicine, Tokai University School of Medicine, Isehara, Japan.
Abstract
BACKGROUND/ OBJECTIVES: To evaluate seasonal fluctuations in intraocular pressure (IOP) in primary open-angle glaucoma (POAG) and its associated factors. SUBJECTS/ METHODS: POAG patients treated only with glaucoma eye drops were enroled. Winter and summer IOPs were evaluated. The Seasonal fluctuation rate of IOP was defined as follows: (mean winter IOP-mean summer IOP)/mean IOP in all seasons. Multiple linear regression analysis was used to explore factors associated with the seasonal IOP fluctuation rate including: age, gender, family history of glaucoma, type of glaucoma, number of eye drops, type of eye drops, mean deviation (MD) value, MD slope, disc haemorrhage, central corneal thickness and spherical equivalent. RESULTS: Winter IOP was higher than summer IOP in 204 POAG eyes of 204 patients, including 162 eyes with normal tension glaucoma (NTG) (13.2 ± 2.7 vs. 12.0 ± 2.3 mmHg, P < 0.001). The mean age and follow-up duration were 63.3 ± 11.4 years and 140.0 ± 66.9 months. Initial MD and MD slope were -2.1 ± 3.4 dB and -0.07 ± 0.50 dB/year, respectively. POAG was positively associated with the rate of seasonal IOP fluctuations compared to NTG (β = 5.29, P = 0.013). Family history, and timolol and carteolol use were also factors associated with the IOP fluctuation rate (β = -6.27, P = 0.007; β = 4.94, P = 0.030; and β = 4.51, P = 0.042, respectively). CONCLUSIONS: We confirmed seasonal IOP fluctuations in POAG. Type of glaucoma, family history of glaucoma, and β-blocker use might influence IOP fluctuations.
BACKGROUND/ OBJECTIVES: To evaluate seasonal fluctuations in intraocular pressure (IOP) in primary open-angle glaucoma (POAG) and its associated factors. SUBJECTS/ METHODS: POAG patients treated only with glaucoma eye drops were enroled. Winter and summer IOPs were evaluated. The Seasonal fluctuation rate of IOP was defined as follows: (mean winter IOP-mean summer IOP)/mean IOP in all seasons. Multiple linear regression analysis was used to explore factors associated with the seasonal IOP fluctuation rate including: age, gender, family history of glaucoma, type of glaucoma, number of eye drops, type of eye drops, mean deviation (MD) value, MD slope, disc haemorrhage, central corneal thickness and spherical equivalent. RESULTS: Winter IOP was higher than summer IOP in 204 POAG eyes of 204 patients, including 162 eyes with normal tension glaucoma (NTG) (13.2 ± 2.7 vs. 12.0 ± 2.3 mmHg, P < 0.001). The mean age and follow-up duration were 63.3 ± 11.4 years and 140.0 ± 66.9 months. Initial MD and MD slope were -2.1 ± 3.4 dB and -0.07 ± 0.50 dB/year, respectively. POAG was positively associated with the rate of seasonal IOP fluctuations compared to NTG (β = 5.29, P = 0.013). Family history, and timolol and carteolol use were also factors associated with the IOP fluctuation rate (β = -6.27, P = 0.007; β = 4.94, P = 0.030; and β = 4.51, P = 0.042, respectively). CONCLUSIONS: We confirmed seasonal IOP fluctuations in POAG. Type of glaucoma, family history of glaucoma, and β-blocker use might influence IOP fluctuations.
Authors: Serge Resnikoff; Donatella Pascolini; Daniel Etya'ale; Ivo Kocur; Ramachandra Pararajasegaram; Gopal P Pokharel; Silvio P Mariotti Journal: Bull World Health Organ Date: 2004-12-14 Impact factor: 9.408
Authors: Christina E Morettin; Daniel K Roberts; Tricia L Newman; Yongyi Yang; Janice M McMahon; Mary Flynn Roberts; Bruce A Teitelbaum; Janis E Winters Journal: J Glaucoma Date: 2021-11-01 Impact factor: 2.503