| Literature DB >> 33526777 |
Luiz Henrique Medeiros Geraldo1,2, Tânia Cristina Leite de Sampaio Spohr3, Rackele Ferreira do Amaral1, Anna Carolina Carvalho da Fonseca4, Celina Garcia1, Fabio de Almeida Mendes1, Catarina Freitas1, Marcos Fabio dosSantos1, Flavia Regina Souza Lima5.
Abstract
Lysophosphatidic acid (LPA) is an abundant bioactive phospholipid, with multiple functions both in development and in pathological conditions. Here, we review the literature about the differential signaling of LPA through its specific receptors, which makes this lipid a versatile signaling molecule. This differential signaling is important for understanding how this molecule can have such diverse effects during central nervous system development and angiogenesis; and also, how it can act as a powerful mediator of pathological conditions, such as neuropathic pain, neurodegenerative diseases, and cancer progression. Ultimately, we review the preclinical and clinical uses of Autotaxin, LPA, and its receptors as therapeutic targets, approaching the most recent data of promising molecules modulating both LPA production and signaling. This review aims to summarize the most update knowledge about the mechanisms of LPA production and signaling in order to understand its biological functions in the central nervous system both in health and disease.Entities:
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Year: 2021 PMID： 33526777 PMCID： PMC7851145 DOI： 10.1038/s41392-020-00367-5
Source DB: PubMed Journal: Signal Transduct Target Ther ISSN： 2059-3635