Literature DB >> 33526776

Piglet immunization with a spike subunit vaccine enhances disease by porcine epidemic diarrhea virus.

Jieshi Yu1, Chithra Sreenivasan1, Tirth Uprety1, Rongyuan Gao2, Chen Huang1, Ella J Lee2, Steven Lawson3, Julie Nelson3, Jane Christopher-Hennings3, Radhey S Kaushik2, Eric Nelson3, Diego G Diel4, Ben M Hause3, Feng Li1, Dan Wang5.   

Abstract

Immunization with an insect cell lysate/baculovirus mixture containing recombinant porcine epidemic diarrhea virus (PEDV) spike protein induced high levels of neutralizing antibodies in both mice and piglets. However, immunization of piglets with this vaccine resulted in enhancement of disease symptoms and virus replication in vaccine recipients exposed to PEDV challenge. Thus, these observations demonstrate a previously unrecognized challenge of PEDV vaccine research, which has important implications for coronavirus vaccine development.

Entities:  

Year:  2021        PMID： 33526776      PMCID： PMC7851141          DOI： 10.1038/s41541-021-00283-x

Source DB:  PubMed          Journal:  NPJ Vaccines        ISSN： 2059-0105            Impact factor:   7.344


  10 in total

1.  Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.

Authors:  Jesper Pallesen; Nianshuang Wang; Kizzmekia S Corbett; Daniel Wrapp; Robert N Kirchdoerfer; Hannah L Turner; Christopher A Cottrell; Michelle M Becker; Lingshu Wang; Wei Shi; Wing-Pui Kong; Erica L Andres; Arminja N Kettenbach; Mark R Denison; James D Chappell; Barney S Graham; Andrew B Ward; Jason S McLellan
Journal:  Proc Natl Acad Sci U S A       Date:  2017-08-14       Impact factor: 11.205

2.  PED virus reinfecting U.S. herds. Virus estimated to have killed 7 million-plus pigs.

Authors:  Greg Cima
Journal:  J Am Vet Med Assoc       Date:  2014-07-15       Impact factor: 1.936

3.  Isolation and characterization of porcine epidemic diarrhea viruses associated with the 2013 disease outbreak among swine in the United States.

Authors:  Qi Chen; Ganwu Li; Judith Stasko; Joseph T Thomas; Wendy R Stensland; Angela E Pillatzki; Phillip C Gauger; Kent J Schwartz; Darin Madson; Kyoung-Jin Yoon; Gregory W Stevenson; Eric R Burrough; Karen M Harmon; Rodger G Main; Jianqiang Zhang
Journal:  J Clin Microbiol       Date:  2013-11-06       Impact factor: 5.948

4.  Emergence of Porcine epidemic diarrhea virus in the United States: clinical signs, lesions, and viral genomic sequences.

Authors:  Gregory W Stevenson; Hai Hoang; Kent J Schwartz; Eric R Burrough; Dong Sun; Darin Madson; Vickie L Cooper; Angela Pillatzki; Philip Gauger; Beverly J Schmitt; Leo G Koster; Mary L Killian; Kyoungjin J Yoon
Journal:  J Vet Diagn Invest       Date:  2013-08-20       Impact factor: 1.279

5.  An mRNA Vaccine against SARS-CoV-2 - Preliminary Report.

Authors:  Lisa A Jackson; Evan J Anderson; Nadine G Rouphael; Paul C Roberts; Mamodikoe Makhene; Rhea N Coler; Michele P McCullough; James D Chappell; Mark R Denison; Laura J Stevens; Andrea J Pruijssers; Adrian McDermott; Britta Flach; Nicole A Doria-Rose; Kizzmekia S Corbett; Kaitlyn M Morabito; Sijy O'Dell; Stephen D Schmidt; Phillip A Swanson; Marcelino Padilla; John R Mascola; Kathleen M Neuzil; Hamilton Bennett; Wellington Sun; Etza Peters; Mat Makowski; Jim Albert; Kaitlyn Cross; Wendy Buchanan; Rhonda Pikaart-Tautges; Julie E Ledgerwood; Barney S Graham; John H Beigel
Journal:  N Engl J Med       Date:  2020-07-14       Impact factor: 91.245

6.  Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.

Authors:  Daniel Wrapp; Nianshuang Wang; Kizzmekia S Corbett; Jory A Goldsmith; Ching-Lin Hsieh; Olubukola Abiona; Barney S Graham; Jason S McLellan
Journal:  Science       Date:  2020-02-19       Impact factor: 47.728

7.  Development of an indirect ELISA, blocking ELISA, fluorescent microsphere immunoassay and fluorescent focus neutralization assay for serologic evaluation of exposure to North American strains of Porcine Epidemic Diarrhea Virus.

Authors:  Faten Okda; Xiaodong Liu; Aaron Singrey; Travis Clement; Julie Nelson; Jane Christopher-Hennings; Eric A Nelson; Steven Lawson
Journal:  BMC Vet Res       Date:  2015-08-01       Impact factor: 2.741

8.  Antibody-dependent infection of human macrophages by severe acute respiratory syndrome coronavirus.

Authors:  Ming Shum Yip; Nancy Hiu Lan Leung; Chung Yan Cheung; Ping Hung Li; Horace Hok Yeung Lee; Marc Daëron; Joseph Sriyal Malik Peiris; Roberto Bruzzone; Martial Jaume
Journal:  Virol J       Date:  2014-05-06       Impact factor: 4.099

Review 9.  An update on feline infectious peritonitis: virology and immunopathogenesis.

Authors:  Niels C Pedersen
Journal:  Vet J       Date:  2014-05-02       Impact factor: 2.688

10.  Antibody-dependent SARS coronavirus infection is mediated by antibodies against spike proteins.

Authors:  Sheng-Fan Wang; Sung-Pin Tseng; Chia-Hung Yen; Jyh-Yuan Yang; Ching-Han Tsao; Chun-Wei Shen; Kuan-Hsuan Chen; Fu-Tong Liu; Wu-Tse Liu; Yi-Ming Arthur Chen; Jason C Huang
Journal:  Biochem Biophys Res Commun       Date:  2014-07-26       Impact factor: 3.575
  10 in total
  5 in total

1.  Systemic Homologous Neutralizing Antibodies Are Inadequate for the Evaluation of Vaccine Protective Efficacy against Coinfection by High Virulent PEDV and PRRSV.

Authors:  Ming Qiu; Shubin Li; Mengxue Ye; Jixiang Li; Zhe Sun; Xinshuai Li; Yulin Xu; Yanzhao Xiao; Chen Li; Binghui Feng; Hong Lin; Wanglong Zheng; Xiuling Yu; Kegong Tian; Jianzhong Zhu; Nanhua Chen
Journal:  Microbiol Spectr       Date:  2022-03-22

2.  Inhibition of a broad range of SARS-CoV-2 variants by antiviral phytochemicals in hACE2 mice.

Authors:  Eun-Ha Kim; Ba Wool Lee; Byeol Ryu; Hyo Moon Cho; Se-Mi Kim; Seung-Gyu Jang; Mark Anthony B Casel; Rare Rollon; Ji-Seung Yoo; Haryoung Poo; Won Keun Oh; Young Ki Choi
Journal:  Antiviral Res       Date:  2022-06-28       Impact factor: 10.103

Review 3.  Antibody-Dependent Enhancement: ″Evil″ Antibodies Favorable for Viral Infections.

Authors:  Xiaoke Yang; Xin Zhang; Xiaotian Zhao; Mengqi Yuan; Kehui Zhang; Jingwen Dai; Xiangyu Guan; Hua-Ji Qiu; Yongfeng Li
Journal:  Viruses       Date:  2022-08-08       Impact factor: 5.818

4.  Enhancing epitope of PEDV spike protein.

Authors:  Techit Thavorasak; Monrat Chulanetra; Kittirat Glab-Ampai; Kodchakorn Mahasongkram; Nawannaporn Sae-Lim; Karsidete Teeranitayatarn; Thaweesak Songserm; Rungrueang Yodsheewan; Dachrit Nilubol; Wanpen Chaicumpa; Nitat Sookrung
Journal:  Front Microbiol       Date:  2022-07-22       Impact factor: 6.064

5.  Novel Neutralizing Epitope of PEDV S1 Protein Identified by IgM Monoclonal Antibody.

Authors:  Techit Thavorasak; Monrat Chulanetra; Kittirat Glab-Ampai; Karsidete Teeranitayatarn; Thaweesak Songserm; Rungrueang Yodsheewan; Nawannaporn Sae-Lim; Porntippa Lekcharoensuk; Nitat Sookrung; Wanpen Chaicumpa
Journal:  Viruses       Date:  2022-01-11       Impact factor: 5.048
  5 in total

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