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Literature DB >> 33526224

Myoepithelial Carcinoma.

Abstract

Myoepithelial carcinoma (MECA) may overlap histologically with other salivary gland neoplasms, especially pleomorphic adenoma. MECA is characterized by cellular, uniform growth of myoepithelial cells and multinodular expansile invasive pattern with zonal cellular distribution. It may arise de novo or in association with pleomorphic adenoma (myoepithelial carcinoma ex pleomorphic adenoma). By immunohistochemistry, MECA is positive for cytokeratins and at least one of the myoepithelial markers, including S100. PLAG1 fusion is the most common genetic alteration. Carcinoma ex pleomorphic adenoma and necrosis correlate with worse clinical outcome in MECA, and necrosis can be used to stratify MECA as high grade.

Entities: Chemical

Keywords: Carcinoma ex pleomorphic adenoma; Myoepithelial carcinoma; PLAG1; Pleomorphic adenoma

Mesh：

Year: 2021 PMID： 33526224 PMCID： PMC8522910 DOI： 10.1016/j.path.2020.09.008

Source DB: PubMed Journal: Surg Pathol Clin ISSN： 1875-9157

18 in total

1. Myoepithelial carcinoma of the salivary glands: a clinicopathologic study of 51 cases in a tertiary cancer center.

Authors: Shubhada V Kane; Izhar N Bagwan
Journal: Arch Otolaryngol Head Neck Surg Date: 2010-07

2. Salivary gland epithelial neoplasms in pediatric population: a single-institute experience with a focus on the histologic spectrum and clinical outcome.

Authors: Bin Xu; Amandeep Aneja; Ronald Ghossein; Nora Katabi
Journal: Hum Pathol Date: 2017-07-21 Impact factor: 3.466

3. Consistent PLAG1 and HMGA2 abnormalities distinguish carcinoma ex-pleomorphic adenoma from its de novo counterparts.

Authors: Nora Katabi; Ronald Ghossein; Alan Ho; Snjezana Dogan; Lei Zhang; Yun-Shao Sung; Cristina R Antonescu
Journal: Hum Pathol Date: 2014-09-07 Impact factor: 3.466

4. Clear cell myoepithelial carcinoma of salivary glands showing EWSR1 rearrangement: molecular analysis of 94 salivary gland carcinomas with prominent clear cell component.

Authors: Alena Skálová; Ilan Weinreb; Martin Hyrcza; Roderick H W Simpson; Jan Laco; Abbas Agaimy; Marina Vazmitel; Hanna Majewska; Tomas Vanecek; Peter Talarčik; Spomenka Manajlovic; Simona N Losito; Petr Šteiner; Adela Klimkova; Michal Michal
Journal: Am J Surg Pathol Date: 2015-03 Impact factor: 6.394

5. PLAG1 gene alterations in salivary gland pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: a combined study using chromosome banding, in situ hybridization and immunocytochemistry.

Authors: Carmo Martins; Isabel Fonseca; Lúcia Roque; Teresa Pereira; Catarina Ribeiro; Jörn Bullerdiek; Jorge Soares
Journal: Mod Pathol Date: 2005-08 Impact factor: 7.842

6. Prognostic factors of recurrence in salivary carcinoma ex pleomorphic adenoma, with emphasis on the carcinoma histologic subtype: a clinicopathologic study of 43 cases.

Authors: Nora Katabi; Daniel Gomez; David S Klimstra; Diane L Carlson; Nancy Lee; Ronald Ghossein
Journal: Hum Pathol Date: 2010-03-24 Impact factor: 3.466

7. PLAG1 alteration in carcinoma ex pleomorphic adenoma: immunohistochemical and fluorescence in situ hybridization studies of 22 cases.

Authors: Armita Bahrami; James D Dalton; Bangalore Shivakumar; Jeffrey F Krane
Journal: Head Neck Pathol Date: 2012-04-08

8. Immunohistochemical and ultrastructural study of malignant plasmacytoid myoepithelioma of the maxillary sinus.

Authors: C H Hsiao; C J Cheng; K L Yeh
Journal: J Formos Med Assoc Date: 1997-03 Impact factor: 3.282

9. Misinterpreted Myoepithelial Carcinoma of Salivary Gland: A Challenging and Potentially Significant Pitfall.

Authors: Bin Xu; Wadad Mneimneh; Dianne E Torrence; Kevin Higgins; David Klimstra; Ronald Ghossein; Nora Katabi
Journal: Am J Surg Pathol Date: 2019-05 Impact factor: 6.394

10. Immunohistochemical features of lacrimal gland epithelial tumors.

Authors: Pia R Mendoza; Frederick A Jakobiec; Jeffrey F Krane
Journal: Am J Ophthalmol Date: 2013-08-20 Impact factor: 5.258

3 in total

1. Expanding the clinicopathological spectrum of TGFBR3-PLAG1 rearranged salivary gland neoplasms with myoepithelial differentiation including evidence of high-grade transformation.

Authors: Niels J Rupp; Sylvia Höller; Muriel Brada; Domenic Vital; Grégoire B Morand; Martina A Broglie; Martin W Huellner; Sandra N Freiberger
Journal: Genes Chromosomes Cancer Date: 2021-11-17 Impact factor: 4.263

2. Glial Fibrillary Acidic Protein Expression Helps Distinguish Pleomorphic Adenoma from Histologic Mimics.

Authors: Zuzanna Gorski; Bibianna Purgina; Jason K Wasserman
Journal: Head Neck Pathol Date: 2022-01-22

3. Parotid Myoepithelial Carcinoma in a Pediatric Patient with Multiple Recurrences: Case Report.

Authors: Harold Bravo Thompson; Maria Lim Law; Ruth Vergara Vasquez; Omar Castillo Fernandez
Journal: Case Rep Oncol Date: 2021-06-24

3 in total