| Literature DB >> 33525971 |
Soudeh Ghafouri-Fard1, Hamed Shoorei2, Mahdi Mohaqiq3, Jamal Majidpoor4, Mohammad Amin Moosavi5, Mohammad Taheri6.
Abstract
As a self-degradative mechanism, macroautophagy/autophagy has a role in the maintenance of energy homeostasis during critical periods in the development of cells. It also controls cellular damage through the eradication of damaged proteins and organelles. This process is accomplished by tens of ATG (autophagy-related) proteins. Recent studies have shown the involvement of non-coding RNAs in the regulation of autophagy. These transcripts mostly modulate the expression of ATG genes. Both long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) have been shown to modulate the autophagy mechanism. Levels of several lncRNAs and miRNAs are altered in this process. In the present review, we discuss the role of lncRNAs and miRNAs in the regulation of autophagy in diverse contexts such as cancer, deep vein thrombosis, spinal cord injury, diabetes and its complications, acute myocardial infarction, osteoarthritis, pre-eclampsia and epilepsy.Abbreviations: AMI: acute myocardial infarction; ATG: autophagy-related; lncRNA: long non-coding RNA; miRNA: microRNA.Entities:
Keywords: Autophagy; biomarker; cancer; lncRNAs; microRNAs
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Year: 2021 PMID： 33525971 PMCID： PMC9196749 DOI： 10.1080/15548627.2021.1883881
Source DB: PubMed Journal: Autophagy ISSN： 1554-8627 Impact factor: 13.391