Literature DB >> 33525396

An Update on Self-Amplifying mRNA Vaccine Development.

Anna K Blakney1, Shell Ip2, Andrew J Geall2.   

Abstract

This review will explore the four major pillars required for design and development of an saRNA vaccine: Antigen design, vector design, non-viral delivery systems, and manufacturing (both saRNA and lipid nanoparticles (LNP)). We report on the major innovations, preclinical and clinical data reported in the last five years and will discuss future prospects.

Entities:  

Keywords:  RNA; drug delivery; replicon; self-amplifying RNA; vaccine

Year:  2021        PMID： 33525396      PMCID： PMC7911542          DOI： 10.3390/vaccines9020097

Source DB:  PubMed          Journal:  Vaccines (Basel)        ISSN： 2076-393X


  152 in total

1.  Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA.

Authors:  Katalin Karikó; Michael Buckstein; Houping Ni; Drew Weissman
Journal:  Immunity       Date:  2005-08       Impact factor: 31.745

Review 2.  The eIF-2alpha kinases and the control of protein synthesis.

Authors:  C de Haro; R Méndez; J Santoyo
Journal:  FASEB J       Date:  1996-10       Impact factor: 5.191

Review 3.  mRNA as a Transformative Technology for Vaccine Development to Control Infectious Diseases.

Authors:  Giulietta Maruggi; Cuiling Zhang; Junwei Li; Jeffrey B Ulmer; Dong Yu
Journal:  Mol Ther       Date:  2019-02-07       Impact factor: 11.454

4.  The 'anti-hype' vaccine.

Authors:  Laura DeFrancesco
Journal:  Nat Biotechnol       Date:  2017-02-27       Impact factor: 54.908

5.  CD8+ T cells mediate protection against Zika virus induced by an NS3-based vaccine.

Authors:  Annie Elong Ngono; Thasneem Syed; Anh-Viet Nguyen; Jose Angel Regla-Nava; Mercylia Susantono; Darina Spasova; Allison Aguilar; Melissa West; Jessica Sparks; Andrew Gonzalez; Emilie Branche; Jason L DeHart; Jerel Boyd Vega; Priya Prakash Karmali; Padmanabh Chivukula; Kurt Kamrud; Parinaz Aliahmad; Nathaniel Wang; Sujan Shresta
Journal:  Sci Adv       Date:  2020-11-04       Impact factor: 14.136

6.  Structural Components for Amplification of Positive and Negative Strand VEEV Splitzicons.

Authors:  Anna K Blakney; Paul F McKay; Robin J Shattock
Journal:  Front Mol Biosci       Date:  2018-07-26

Review 7.  A Comparison of Plasmid DNA and mRNA as Vaccine Technologies.

Authors:  Margaret A Liu
Journal:  Vaccines (Basel)       Date:  2019-04-24

8.  A pneumonia outbreak associated with a new coronavirus of probable bat origin.

Authors:  Peng Zhou; Xing-Lou Yang; Xian-Guang Wang; Ben Hu; Lei Zhang; Wei Zhang; Hao-Rui Si; Yan Zhu; Bei Li; Chao-Lin Huang; Hui-Dong Chen; Jing Chen; Yun Luo; Hua Guo; Ren-Di Jiang; Mei-Qin Liu; Ying Chen; Xu-Rui Shen; Xi Wang; Xiao-Shuang Zheng; Kai Zhao; Quan-Jiao Chen; Fei Deng; Lin-Lin Liu; Bing Yan; Fa-Xian Zhan; Yan-Yi Wang; Geng-Fu Xiao; Zheng-Li Shi
Journal:  Nature       Date:  2020-02-03       Impact factor: 69.504

Review 9.  A novel, disruptive vaccination technology: self-adjuvanted RNActive(®) vaccines.

Authors:  Karl-Josef Kallen; Regina Heidenreich; Margit Schnee; Benjamin Petsch; Thomas Schlake; Andreas Thess; Patrick Baumhof; Birgit Scheel; Sven D Koch; Mariola Fotin-Mleczek
Journal:  Hum Vaccin Immunother       Date:  2013-06-04       Impact factor: 3.452

10.  Big Is Beautiful: Enhanced saRNA Delivery and Immunogenicity by a Higher Molecular Weight, Bioreducible, Cationic Polymer.

Authors:  Anna K Blakney; Yunqing Zhu; Paul F McKay; Clément R Bouton; Jonathan Yeow; Jiaqing Tang; Kai Hu; Karnyart Samnuan; Christopher L Grigsby; Robin J Shattock; Molly M Stevens
Journal:  ACS Nano       Date:  2020-04-20       Impact factor: 15.881
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  31 in total

Review 1.  Recent advances in nanotechnology-based COVID-19 vaccines and therapeutic antibodies.

Authors:  Lanying Du; Yang Yang; Xiujuan Zhang; Fang Li
Journal:  Nanoscale       Date:  2022-01-27       Impact factor: 7.790

Review 2.  Nanotechnology-Assisted RNA Delivery: From Nucleic Acid Therapeutics to COVID-19 Vaccines.

Authors:  Chiara Rinoldi; Seyed Shahrooz Zargarian; Pawel Nakielski; Xiaoran Li; Anna Liguori; Francesca Petronella; Dario Presutti; Qiusheng Wang; Marco Costantini; Luciano De Sio; Chiara Gualandi; Bin Ding; Filippo Pierini
Journal:  Small Methods       Date:  2021-07-28

Review 3.  mRNA-based modalities for infectious disease management.

Authors:  Mengjie Zhang; Abid Hussain; Haiyin Yang; Jinchao Zhang; Xing-Jie Liang; Yuanyu Huang
Journal:  Nano Res       Date:  2022-07-06       Impact factor: 10.269

4.  Perspectives on scaling production of adipose tissue for food applications.

Authors:  John S K Yuen; Andrew J Stout; N Stephanie Kawecki; Sophia M Letcher; Sophia K Theodossiou; Julian M Cohen; Brigid M Barrick; Michael K Saad; Natalie R Rubio; Jaymie A Pietropinto; Hailey DiCindio; Sabrina W Zhang; Amy C Rowat; David L Kaplan
Journal:  Biomaterials       Date:  2021-11-29       Impact factor: 15.304

Review 5.  Transdermal delivery for gene therapy.

Authors:  Parbeen Singh; I'jaaz Muhammad; Nicole E Nelson; Khanh T M Tran; Tra Vinikoor; Meysam T Chorsi; Ethan D'Orio; Thanh D Nguyen
Journal:  Drug Deliv Transl Res       Date:  2022-05-10       Impact factor: 5.671

Review 6.  An update on novel approaches for diagnosis and treatment of SARS-CoV-2 infection.

Authors:  Azadeh Safarchi; Shadma Fatima; Zahra Ayati; Fatemeh Vafaee
Journal:  Cell Biosci       Date:  2021-08-22       Impact factor: 7.133

7.  mRNA Innovates the Vaccine Field.

Authors:  Norbert Pardi
Journal:  Vaccines (Basel)       Date:  2021-05-11

Review 8.  Non-Immunotherapy Application of LNP-mRNA: Maximizing Efficacy and Safety.

Authors:  Irena Vlatkovic
Journal:  Biomedicines       Date:  2021-05-10

Review 9.  Adenoviral vector vaccine platforms in the SARS-CoV-2 pandemic.

Authors:  Samir Andrade Mendonça; Reka Lorincz; Paul Boucher; David T Curiel
Journal:  NPJ Vaccines       Date:  2021-08-05       Impact factor: 7.344

Review 10.  Synthesis and Potential Applications of Lipid Nanoparticles in Medicine.

Authors:  Ewelina Musielak; Agnieszka Feliczak-Guzik; Izabela Nowak
Journal:  Materials (Basel)       Date:  2022-01-17       Impact factor: 3.623
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