Allen L Ho1, Austin Y Feng1, Daniel A N Barbosa1, Hemmings Wu1, Monique L Smith2, Robert C Malenka2, Peter A Tass1, Casey H Halpern3. 1. Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, 94305, USA. 2. Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA. 3. Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, 94305, USA. Electronic address: chalpern@stanford.edu.
Abstract
BACKGROUND: Alcohol use disorder (AUD) affects nearly 5% of the world's adult population. Despite treatment, AUD often manifests with relapse to binge drinking, which has been associated with corticostriatal hypersynchrony involving the nucleus accumbens (NAc). METHODS: A modified "Drinking in the Dark" protocol was used to provoke binge-like alcohol drinking. We implemented Coordinated Reset Stimulation (CRS), a computationally designed, spatio-temporal stimulation algorithm, to desynchronize abnormal neuronal activity via a deep brain stimulation (DBS) electrode in the NAc of mice exhibiting binge-like alcohol drinking. Integral CRS charge injected would be 2.5% of that of conventional high-frequency DBS. RESULTS: NAc CRS delivery during only the initial phase of exposure to alcohol and prior to the exposure (but not during) significantly reduced binge-like drinking without interfering with social behavior or locomotor activity. CONCLUSIONS: NAc CRS ameliorates binge-like alcohol drinking and preliminarily exhibits sustained aftereffects that are suggestive of an unlearning of hypersynchrony.
BACKGROUND:Alcohol use disorder (AUD) affects nearly 5% of the world's adult population. Despite treatment, AUD often manifests with relapse to binge drinking, which has been associated with corticostriatal hypersynchrony involving the nucleus accumbens (NAc). METHODS: A modified "Drinking in the Dark" protocol was used to provoke binge-like alcohol drinking. We implemented Coordinated Reset Stimulation (CRS), a computationally designed, spatio-temporal stimulation algorithm, to desynchronize abnormal neuronal activity via a deep brain stimulation (DBS) electrode in the NAc of mice exhibiting binge-like alcohol drinking. Integral CRS charge injected would be 2.5% of that of conventional high-frequency DBS. RESULTS: NAc CRS delivery during only the initial phase of exposure to alcohol and prior to the exposure (but not during) significantly reduced binge-like drinking without interfering with social behavior or locomotor activity. CONCLUSIONS: NAc CRS ameliorates binge-like alcohol drinking and preliminarily exhibits sustained aftereffects that are suggestive of an unlearning of hypersynchrony.
Authors: Hemmings Wu; Bina Kakusa; Sophie Neuner; Daniel J Christoffel; Boris D Heifets; Robert C Malenka; Casey H Halpern Journal: Proc Natl Acad Sci U S A Date: 2022-01-04 Impact factor: 11.205
Authors: Joshua K Wong; Günther Deuschl; Robin Wolke; Hagai Bergman; Muthuraman Muthuraman; Sergiu Groppa; Sameer A Sheth; Helen M Bronte-Stewart; Kevin B Wilkins; Matthew N Petrucci; Emilia Lambert; Yasmine Kehnemouyi; Philip A Starr; Simon Little; Juan Anso; Ro'ee Gilron; Lawrence Poree; Giridhar P Kalamangalam; Gregory A Worrell; Kai J Miller; Nicholas D Schiff; Christopher R Butson; Jaimie M Henderson; Jack W Judy; Adolfo Ramirez-Zamora; Kelly D Foote; Peter A Silburn; Luming Li; Genko Oyama; Hikaru Kamo; Satoko Sekimoto; Nobutaka Hattori; James J Giordano; Diane DiEuliis; John R Shook; Darin D Doughtery; Alik S Widge; Helen S Mayberg; Jungho Cha; Kisueng Choi; Stephen Heisig; Mosadolu Obatusin; Enrico Opri; Scott B Kaufman; Prasad Shirvalkar; Christopher J Rozell; Sankaraleengam Alagapan; Robert S Raike; Hemant Bokil; David Green; Michael S Okun Journal: Front Hum Neurosci Date: 2022-03-04 Impact factor: 3.473