Literature DB >> 33524090

Antiviral drug discovery: preparing for the next pandemic.

Catherine S Adamson1, Kelly Chibale, Rebecca J M Goss, Marcel Jaspars, David J Newman, Rosemary A Dorrington.   

Abstract

Clinically approved antiviral drugs are currently available for only 10 of the more than 220 viruses known to infect humans. The SARS-CoV-2 outbreak has exposed the critical need for compounds that can be rapidly mobilised for the treatment of re-emerging or emerging viral diseases, while vaccine development is underway. We review the current status of antiviral therapies focusing on RNA viruses, highlighting strategies for antiviral drug discovery and discuss the challenges, solutions and options to accelerate drug discovery efforts.

Entities:  

Mesh：

Substances：

Year:  2021        PMID： 33524090     DOI： 10.1039/d0cs01118e

Source DB:  PubMed          Journal:  Chem Soc Rev        ISSN： 0306-0012            Impact factor:   54.564


  20 in total

1.  Selective Inhibition of Murine Cytomegalovirus Viral Gene Expression by the Antiviral Peptide TAT-I24.

Authors:  Hanna Harant
Journal:  Int J Mol Sci       Date:  2022-06-29       Impact factor: 6.208

2.  Streptomyces coeruleorubidus as a potential biocontrol agent for Newcastle disease virus.

Authors:  Rewan Abdelaziz; Yasmine H Tartor; Ahmed B Barakat; Gamal El-Didamony; Hanaa A El-Samadony; Shimaa A Amer; Marwa M Gado
Journal:  BMC Vet Res       Date:  2022-06-24       Impact factor: 2.792

Review 3.  Resources and computational strategies to advance small molecule SARS-CoV-2 discovery: lessons from the pandemic and preparing for future health crises.

Authors:  Natesh Singh; Bruno O Villoutreix
Journal:  Comput Struct Biotechnol J       Date:  2021-04-26       Impact factor: 7.271

4.  Sinapic Acid Suppresses SARS CoV-2 Replication by Targeting Its Envelope Protein.

Authors:  Raha Orfali; Mostafa E Rateb; Hossam M Hassan; Mona Alonazi; Mokhtar R Gomaa; Noura Mahrous; Mohamed GabAllah; Ahmed Kandeil; Shagufta Perveen; Usama Ramadan Abdelmohsen; Ahmed M Sayed
Journal:  Antibiotics (Basel)       Date:  2021-04-11

Review 5.  Photosensitizing Antivirals.

Authors:  Kseniya A Mariewskaya; Anton P Tyurin; Alexey A Chistov; Vladimir A Korshun; Vera A Alferova; Alexey V Ustinov
Journal:  Molecules       Date:  2021-06-29       Impact factor: 4.411

6.  Olive-Derived Triterpenes Suppress SARS COV-2 Main Protease: A Promising Scaffold for Future Therapeutics.

Authors:  Hani A Alhadrami; Ahmed M Sayed; Ahmed M Sharif; Esam I Azhar; Mostafa E Rateb
Journal:  Molecules       Date:  2021-05-01       Impact factor: 4.411

7.  Scaffold Hopping of α-Rubromycin Enables Direct Access to FDA-Approved Cromoglicic Acid as a SARS-CoV-2 MPro Inhibitor.

Authors:  Hani A Alhadrami; Ahmed M Sayed; Heba Al-Khatabi; Nabil A Alhakamy; Mostafa E Rateb
Journal:  Pharmaceuticals (Basel)       Date:  2021-06-05

Review 8.  Antiviral Strategies Using Natural Source-Derived Sulfated Polysaccharides in the Light of the COVID-19 Pandemic and Major Human Pathogenic Viruses.

Authors:  Bimalendu Ray; Imran Ali; Subrata Jana; Shuvam Mukherjee; Saikat Pal; Sayani Ray; Martin Schütz; Manfred Marschall
Journal:  Viruses       Date:  2021-12-24       Impact factor: 5.048

9.  Development of targeted nanoparticles loaded with antiviral drugs for SARS-CoV-2 inhibition.

Authors:  Vanna Sanna; Sandro Satta; Tzung Hsiai; Mario Sechi
Journal:  Eur J Med Chem       Date:  2022-01-13       Impact factor: 6.514

Review 10.  An unexpected biomaterial against SARS-CoV-2: Bio-polyphosphate blocks binding of the viral spike to the cell receptor.

Authors:  Werner E G Müller; Heinz C Schröder; Meik Neufurth; Xiaohong Wang
Journal:  Mater Today (Kidlington)       Date:  2021-08-02       Impact factor: 31.041
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.