Abdurakhmon T Babakhanov1, Aueskhan T Dzhumabekov2, Alexey V Zhao3, Yerlan K Kuandykov4, Shynar B Tanabayeva5, Ildar R Fakhradiyev5, Yana Nazarenko5, Timur M Saliev5. 1. Central City Clinical Hospital No. 12, Almaty, Kazakhstan. 2. Kazakh Medical University of Continuing Education, Almaty, Kazakhstan. 3. Institute of Surgery named after A.V. Vishnevsky, Moscow, Russia. 4. Khoja Akhmet Yassawi International Kazakh-Turkish University, Shymkent Medical Institute Postgraduate Studies Faculty, Shymkent, Kazakhstan. 5. S.D. Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
Abstract
Background: Considered vestigial from the classic point of view, the vermiform appendix has long been the subject of intensive studies. The recent understanding of appendix function in the context of unique architecture and bacterial complexity and density allows considering it as a safehouse for intestinal biodiversity. Methods: This review analyzes and assesses the current state of scientific knowledge regarding the role of the vermiform appendix in normal gut microbiota maintenance as a crucial factor of host homeostasis. It also highlights the difference in microbial composition between the large bowel and the appendix, as well as the association between the surgical excision, appendectomy, and dysbiosis-induced diseases. In addition, the review discusses the results of epidemiologic studies on appendectomy as a risk factor for the initiation of gastrointestinal carcinogenesis. It also highlights the association between appendectomy and a series of chronic inflammatory and neurologic disorders, including inflammatory bowel disease.
Background: Considered vestigial from the classic point of view, the vermiform appendix has long been the subject of intensive studies. The recent understanding of appendix function in the context of unique architecture and bacterial complexity and density allows considering it as a safehouse for intestinal biodiversity. Methods: This review analyzes and assesses the current state of scientific knowledge regarding the role of the vermiform appendix in normal gut microbiota maintenance as a crucial factor of host homeostasis. It also highlights the difference in microbial composition between the large bowel and the appendix, as well as the association between the surgical excision, appendectomy, and dysbiosis-induced diseases. In addition, the review discusses the results of epidemiologic studies on appendectomy as a risk factor for the initiation of gastrointestinal carcinogenesis. It also highlights the association between appendectomy and a series of chronic inflammatory and neurologic disorders, including inflammatory bowel disease.
Entities:
Keywords:
appendectomy; appendicitis; dysbiosis; gut microbiome; microbiology
Authors: Zlatan Mujagic; Melpomeni Kasapi; Daisy Mae Jonkers; Isabel Garcia-Perez; Lisa Vork; Zsa Zsa R M Weerts; Jose Ivan Serrano-Contreras; Alexandra Zhernakova; Alexander Kurilshikov; Jamie Scotcher; Elaine Holmes; Cisca Wijmenga; Daniel Keszthelyi; Jeremy K Nicholson; Joram M Posma; Ad Am Masclee Journal: Gut Microbes Date: 2022 Jan-Dec