Wanli Bi1, Shuo Zhao2, Chongchong Wu3, Jie Gao4, Shaohong Zhao3, Shifeng Yang2, Yan Deng5, Pei Nie6, Xinxin Yu2, Hui Deng7, Xuelei Zang8, Xidong Ma9, Jun Han10, Idorenyin Asuquo11, Ximing Wang2, Xinying Xue7,12,13,14. 1. Department of Radiology, Shandong Medical Imaging Research Institute, Shandong University, Jinan, China. 2. Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. 3. Department of Radiology, The Chinese PLA General Hospital, Beijing, China. 4. Department of Pathology, The Chinese PLA General Hospital, Beijing, China. 5. Department of Radiology, Qilu Hospital, Shandong University, Jinan, Shandong, China. 6. Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China. 7. Department of Respiratory and Critical Care, Beijing Shijitan Hospital, Capital Medical University, Beijing, China. 8. Department of Microbiology, The Chinese PLA General Hospital, Beijing, China. 9. Department of Respiratory Disease, School of Clinical Medicine, Weifang Medical University, Weifang, Shandong, China. 10. Department of Radiology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China. 11. Department of and Respiratory, Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China. 12. Peking University Ninth School of Clinical Medicine, Beijing, China. 13. Department of Respiratory and Critical Care, Chinese PLA General Hospital, Beijing, China. 14. Affiliated Hospital of Weifang Medical University, Shandong, China.
Abstract
BACKGROUND: Pulmonary mucosa-associated lymphoid tissue lymphoma (MALToma) is the most frequent subset of primary pulmonary lymphoma. This study aimed to identify radiologic characteristics of pulmonary MALToma based on computed tomography (CT) observations and pathologic features, and further investigate its prognosis. METHODS: Sixty-six patients (55.4 ± 10.9 years; 51.5% male) diagnosed as pulmonary MALToma by pathology were retrospectively enrolled. According to distributions and features of lesions shown on CT, patients were divided into three patterns, including single nodular/mass, multiple nodular/mass, and pneumonia-like consolidative. RESULTS: Variety of the location and extent of the lymphomatous infiltration accounted for different characteristics demonstrated at CT. The pneumonia-like consolidative pattern was the most frequent pattern observed in 42 patients (63.6%), followed by single nodular/mass (21.2%) and multiple nodular/mass (15.2%). CT features included air bronchogram (72.7%), well-marginated halo sign (53.0%), coarse spiculate with different lengths (72.7%), angiogram sign (77.1% of 35 patients), peribronchovascular thickening (48.5%), irregular cavitation (16.7%) and pulmonary cyst (7.6%). The estimated 5-year cumulative overall survival rate of pulmonary MALToma was 100.0%. CONCLUSIONS: Pulmonary MALToma demonstrates several characteristics at CT. Identification of the significant pulmonary abnormalities of this indolent disease entity might be helpful for early diagnosis and optimal treatment.
BACKGROUND: Pulmonary mucosa-associated lymphoid tissue lymphoma (MALToma) is the most frequent subset of primary pulmonary lymphoma. This study aimed to identify radiologic characteristics of pulmonary MALToma based on computed tomography (CT) observations and pathologic features, and further investigate its prognosis. METHODS: Sixty-six patients (55.4 ± 10.9 years; 51.5% male) diagnosed as pulmonary MALToma by pathology were retrospectively enrolled. According to distributions and features of lesions shown on CT, patients were divided into three patterns, including single nodular/mass, multiple nodular/mass, and pneumonia-like consolidative. RESULTS: Variety of the location and extent of the lymphomatous infiltration accounted for different characteristics demonstrated at CT. The pneumonia-like consolidative pattern was the most frequent pattern observed in 42 patients (63.6%), followed by single nodular/mass (21.2%) and multiple nodular/mass (15.2%). CT features included air bronchogram (72.7%), well-marginated halo sign (53.0%), coarse spiculate with different lengths (72.7%), angiogram sign (77.1% of 35 patients), peribronchovascular thickening (48.5%), irregular cavitation (16.7%) and pulmonary cyst (7.6%). The estimated 5-year cumulative overall survival rate of pulmonary MALToma was 100.0%. CONCLUSIONS:Pulmonary MALToma demonstrates several characteristics at CT. Identification of the significant pulmonary abnormalities of this indolent disease entity might be helpful for early diagnosis and optimal treatment.