| Literature DB >> 3352272 |
M Y Yeh1, D S Yü, S C Chen, M S Lin, S Y Chang, C P Ma, S H Han.
Abstract
A cell line derived from a well-differentiated human transitional cell carcinoma of the urinary bladder, designated TSGH-8301, was established in vitro. The cultured epithelioid cells exhibited monolayer growth and loss of contact inhibition. The tumorigenicity of TSGH-8301 had been shown by growth in soft agar and tumor induction in athymic nude mice. A reverse ratio of lactate dehydrogenase (LHD) isoenzyme in the cell line and nude mouse-grown tumors was seen predominantly with LDH-V. Chromosomal analysis revealed a heterodiploid stem line with a modal number of 50. Sera of urinary bladder cancer patients reacted with membrane antigens of the TSGH-8301 cells, suggesting the existence of tumor-associated antigens in the cells. In vitro chemosensitivity tests of these cells may provide data valuable in the selection of proper anticancer drugs for the TSGH-8301 donor patient.Entities:
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Year: 1988 PMID： 3352272 DOI： 10.1002/jso.2930370310
Source DB: PubMed Journal: J Surg Oncol ISSN： 0022-4790 Impact factor: 3.454