Wen Hao1,2, Xiao Wang1,2, Jingyao Fan1,2, Yaping Zeng1,2, Hui Ai1,2, Shaoping Nie1,2, Yongxiang Wei2,3. 1. Emergency and Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. 2. Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China. 3. Department of Otolaryngology Head and Neck Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Abstract
BACKGROUND: The present study aimed to evaluate the association between presence and severity of obstructive sleep apnoea (OSA) and the presence of subclinical coronary artery disease (CAD) as assessed by coronary calcium score. METHODS: Medline, Cochrane, and Google Scholar databases were searched. The presence of coronary artery calcification (CAC) and CAC score were assessed. RESULTS: Irrespective of the cut-off value of apnoea-hypopnea index (AHI) (5 or 15 events/h), patients in the OSA group had higher rate of CAC presence and mean CAC score than those in the control group. Subgroup analyses of patients monitored with home sleep apnoea testing (HSAT) or in-hospital/laboratory polysomnography showed that the OSA group had higher rate of CAC presence and mean CAC score than the control group, except in the comparison of mean CAC score between AHI ≥5 vs. <5 events/h for patients using HSAT, which was not significant. Pair-wise comparison showed that CAC score may increase with increased OSA severity. CONCLUSIONS: In participants without symptomatic coronary disease, the presence of OSA was associated with the presence and extent of CAC. However, potential confounders such as age, gender, and BMI and the diversity of CAC scores may affect the association.
BACKGROUND: The present study aimed to evaluate the association between presence and severity of obstructive sleep apnoea (OSA) and the presence of subclinical coronary artery disease (CAD) as assessed by coronary calcium score. METHODS: Medline, Cochrane, and Google Scholar databases were searched. The presence of coronary artery calcification (CAC) and CAC score were assessed. RESULTS: Irrespective of the cut-off value of apnoea-hypopnea index (AHI) (5 or 15 events/h), patients in the OSA group had higher rate of CAC presence and mean CAC score than those in the control group. Subgroup analyses of patients monitored with home sleep apnoea testing (HSAT) or in-hospital/laboratory polysomnography showed that the OSA group had higher rate of CAC presence and mean CAC score than the control group, except in the comparison of mean CAC score between AHI ≥5 vs. <5 events/h for patients using HSAT, which was not significant. Pair-wise comparison showed that CAC score may increase with increased OSA severity. CONCLUSIONS: In participants without symptomatic coronary disease, the presence of OSA was associated with the presence and extent of CAC. However, potential confounders such as age, gender, and BMI and the diversity of CAC scores may affect the association.
Authors: Alessandro Liberati; Douglas G Altman; Jennifer Tetzlaff; Cynthia Mulrow; Peter C Gøtzsche; John P A Ioannidis; Mike Clarke; P J Devereaux; Jos Kleijnen; David Moher Journal: J Clin Epidemiol Date: 2009-07-23 Impact factor: 6.437
Authors: Juan F Masa; Jaime Corral; Ricardo Pereira; Joaquin Duran-Cantolla; Marta Cabello; Luis Hernández-Blasco; Carmen Monasterio; Alberto Alonso; Eusebi Chiner; Manuela Rubio; Estefania Garcia-Ledesma; Laura Cacelo; Rosario Carpizo; Lirios Sacristan; Neus Salord; Miguel Carrera; José N Sancho-Chust; Cristina Embid; Francisco-José Vázquez-Polo; Miguel A Negrín; Jose M Montserrat Journal: Thorax Date: 2011-05-20 Impact factor: 9.139
Authors: Daniel Shpilsky; Sebhat Erqou; Sanjay R Patel; Kevin E Kip; Oluremi Ajala; Aryan Aiyer; Patrick J Strollo; Steven E Reis; Oladipupo Olafiranye Journal: Vasc Med Date: 2018-03-14 Impact factor: 3.239
Authors: Raimund Erbel; Nils Lehmann; Stefan Möhlenkamp; Sofia Churzidse; Marcus Bauer; Hagen Kälsch; Axel Schmermund; Susanne Moebus; Andreas Stang; Ulla Roggenbuck; Martina Bröcker-Preuss; Nico Dragano; Christian Weimar; Johannes Siegrist; Karl-Heinz Jöckel Journal: Hypertension Date: 2011-11-28 Impact factor: 10.190
Authors: Robert Detrano; Alan D Guerci; J Jeffrey Carr; Diane E Bild; Gregory Burke; Aaron R Folsom; Kiang Liu; Steven Shea; Moyses Szklo; David A Bluemke; Daniel H O'Leary; Russell Tracy; Karol Watson; Nathan D Wong; Richard A Kronmal Journal: N Engl J Med Date: 2008-03-27 Impact factor: 91.245