Literature DB >> 3351931

Structure of tumour necrosis factor by X-ray solution scattering and preliminary studies by single crystal X-ray diffraction.

A Lewit-Bentley1, R Fourme, R Kahn, T Prangé, P Vachette, J Tavernier, G Hauquier, W Niers.   

Abstract

The structure of tumour necrosis factor has been investigated by X-ray small-angle scattering and X-ray diffraction using synchrotron radiation. The overall radius of gyration is 25.5 A. A plausible model accounting for the scattering curves consists of an elongated trimer with an axial ratio of 3 to 4 and a maximal chord with a lower limit of 80 A. Tumour necrosis factor has been crystallized in a trigonal space group. Our results are in favour of a single trimer in the asymmetric unit. The diffraction extends to 3.5 A.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 3351931     DOI： 10.1016/0022-2836(88)90323-3

Source DB:  PubMed          Journal:  J Mol Biol        ISSN： 0022-2836            Impact factor:   5.469


  8 in total

1.  Thiolated recombinant human tumor necrosis factor-alpha protects against Plasmodium berghei K173-induced experimental cerebral malaria in mice.

Authors:  N S Postma; R C Hermsen; D J Crommelin; W M Eling; J Zuidema
Journal:  Antimicrob Agents Chemother       Date:  1999-05       Impact factor: 5.191

2.  Oligomeric tumour necrosis factor alpha slowly converts into inactive forms at bioactive levels.

Authors:  A Corti; G Fassina; F Marcucci; E Barbanti; G Cassani
Journal:  Biochem J       Date:  1992-06-15       Impact factor: 3.857

3.  Recognition of human tumor necrosis factor α (TNF-α) by therapeutic antibody fragment: energetics and structural features.

Authors:  Jaka Marušič; Črtomir Podlipnik; Simona Jevševar; Drago Kuzman; Gorazd Vesnaver; Jurij Lah
Journal:  J Biol Chem       Date:  2012-01-19       Impact factor: 5.157

4.  Characterization of a tumor necrosis factor alpha (TNF-alpha) inhibitor: evidence of immunological cross-reactivity with the TNF receptor.

Authors:  P Seckinger; J H Zhang; B Hauptmann; J M Dayer
Journal:  Proc Natl Acad Sci U S A       Date:  1990-07       Impact factor: 11.205

5.  Crystal structure of the TRANCE/RANKL cytokine reveals determinants of receptor-ligand specificity.

Authors:  J Lam; C A Nelson; F P Ross; S L Teitelbaum; D H Fremont
Journal:  J Clin Invest       Date:  2001-10       Impact factor: 14.808

6.  Localization of the active site of human tumour necrosis factor (hTNF) by mutational analysis.

Authors:  X Van Ostade; J Tavernier; T Prangé; W Fiers
Journal:  EMBO J       Date:  1991-04       Impact factor: 11.598

7.  Peptide hydrogel in vitro non-inflammatory potential.

Authors:  A Markey; V L Workman; I A Bruce; T J Woolford; B Derby; A F Miller; S H Cartmell; A Saiani
Journal:  J Pept Sci       Date:  2016-12-19       Impact factor: 1.905

8.  Functional characterization of the human tumor necrosis factor receptor p75 in a transfected rat/mouse T cell hybridoma.

Authors:  P Vandenabeele; W Declercq; D Vercammen; M Van de Craen; J Grooten; H Loetscher; M Brockhaus; W Lesslauer; W Fiers
Journal:  J Exp Med       Date:  1992-10-01       Impact factor: 14.307
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.