Primary Mature Teratoma of the Rectum: A Case Report.

BACKGROUND Teratomas are embryonal neoplasms that contain tissues derived from 1 or more of the 3 germ layers. They commonly are found in the sacrococcygeal-gonadal location, sometimes in midline locations such as the mediastinum, retroperitoneum, and head and neck region. Primary rectal teratomas are extremely rare. Extragonadal teratomas can originate from pluripotent germ cells present in abnormal embryonic rests. CASE REPORT Here, we report a rare case of a primary mature, solid teratoma of the rectum. A 68-year-old woman presented with hematochezia and denied any history of abdominal pain or a change in bowel habits. Colonoscopy revealed a 4-cm pedunculated polyp in the rectum. No hair was present on its surface. The polyp was completely removed by polypectomy. Histologically, the tumor consisted of mature components from all 3 germ layers. Its surface was covered by squamous epithelium with hair follicles and sweat glands. Adipose tissue, blood vessels, bone, and glandular epithelium were present inside the mass. No evidence was found of immature elements or malignant features. CONCLUSIONS When polypoid lesions are found in the rectum, teratoma should be considered in the differential diagnosis. Histopathological confirmation is necessary to diagnose teratoma. Primary rectal teratomas should be distinguished from other neoplastic polyps as well as from local spread of teratomas arising in adjacent organs. These neoplasms are usually mature (benign) but may undergo malignant transformation. Therefore, complete resection is recommended to alleviate symptoms and avoid the risk of malignancy.

Background

Teratomas are embryonal neoplasms that contain tissues derived from 1 or more of the 3 germ layers: ectoderm, mesoderm, and endoderm [1]. They are commonly found in the sacrococcygeal-gonadal area and sometimes in midline locations such as the mediastinum, retroperitoneum, and head and neck [1]. Primary rectal teratomas are extremely rare [2]. Most are mature and occur in women [3]. In most reported cases, teratomas have been pedunculated, which leads to symptoms such as prolapse of the mass or hair [3]. We report a case of a primary, mature, solid teratoma of the rectum that was a pedunculated polyp and which was successfully removed with endoscopic resection.

Case Report

A 68-year-old woman presented with hematochezia. She denied any history of abdominal pain, constipation, or weight loss. She had no significant history of medical problems, except for hypertension. Physical examination revealed no abnormalities. Colonoscopy revealed a 4-cm pedunculated polyp located approximately 15 cm from the anal verge (). A large part of the outer surface of the polyp was ulcerated, and the remaining surface was covered with white-to-gray, wrinkled mucosa. Colonoscopy showed no evidence of other polyps. The polyp was clinically suspected to be an epithelial tumor such as an adenoma/carcinoma or a hamartomatous polyp. The mass was removed by polypectomy. On gross examination, the specimen measured 4.2×3.5×3.0 cm and had a 1.0-cm stalk (). The cut surface of the mass was solid, with yellow adipose and hard, bony tissue (). No hair or sebaceous material was found. On microscopic examination, the ulcerated part of the tumor surface showed inflamed granulation tissue with hemorrhage, whereas the intact part was covered by squamous epithelium (). Hair follicles and sweat glands were present below the surface (). Adipose tissue, blood vessels, bone, and glandular epithelium were present inside the mass (). There was no evidence of immature elements or malignant features. Based on these findings, a diagnosis of primary mature teratoma of the rectum was made. The patient recovered with no complications and will undergo an abdominal computed tomography (CT) scan at a follow-up visit.

Discussion

Teratomas may have their origins in pluripotent germ cells, which are abundant in the gonads [1]; during embryogenesis, some primordial germ cells may follow abnormal migratory pathways and lodge in extragonadal sites. Stray germ cells usually degenerate, but in rare cases, they remain at ectopic locations and can develop into teratomas [4].

In 2009, Park et al reported on a case and reviewed 55 other cases of teratoma that had previously been reported worldwide [2]. In an extensive review of reports, we found 9 more case reports up until 2020, not including the present case [3,5-12]. In 65 cases, most primary rectal teratomas were mature (benign). Sixty-four were diagnosed in women [13], which is not surprising because germ cells from the ovaries can migrate to the rectum [14]. The age range of patients with primary rectal tumors was 2 to 83 years, with most cases in individuals in their 20s to 40s [2,3,11]. In contrast, teratomas of the gastric and sacrococcygeal regions are mainly diagnosed in neonates and infants [1].

A review of the literature by Park et al [2] revealed that the most common symptoms of primary rectal teratomas were prolapse of the mass and/or hair (22 cases, 42.3%), hematochezia (18 cases, 34.6%), and constipation (10 cases, 19.2%). However, lower abdominal pain, abdominal mass, and low back pain occasionally has been reported. Among the 9 additional cases we found, there was a single patient with prolapse of a mass [12], 2 patients had hematochezia with pain [8,9], and 3 had constipation [3,6,11]. The patient in the present case presented with painless hematochezia. The differential diagnosis for it includes colonic diverticulosis (the most common cause), angiodysplasias, nonsteroidal anti-inflammatory drug-associated ulcers, and colon polyps/neoplasms [15,16]. Most of the tumors we found were polypoid in shape and only 4 cases presented as submucosal cysts [17]. The polypoid masses were mostly pedunculated. The tumors ranged in size from 1.2 to 15 cm [3]. In the reported cases, the ovarian teratomas were almost always cystic, whereas primary rectal teratomas were frequently solid [3]. Histologically, most primary rectal teratomas are composed of derivatives from all 3 germ layers, but a few cases of dermoid cysts of the rectum have been reported [17,18]. Only 1 case of immature teratoma, found in a 2-year-old girl, has been reported [12].

When hair is identified on the tumor surface or squamous epithelium in a biopsy sample, suspicion should be high for teratoma [14]. In most of the reported cases of rectal teratoma, hairs were present on the surface. However, if hair is not present on the polyp, the diagnosis of teratoma is rarely considered because of its rarity in the rectum [14]. The differential diagnosis includes various adenomas, carcinomas, leiomyomas, lymphomas, carcinoid tumors, lipomas, and vascular neoplasms [19]. In our case, because the polyp was pedunculated with a well-defined stalk and there were no hairs seen on endoscopy, it was clinically suspected to be an epithelial tumor, such as an adenoma/carcinoma or a hamartomatous polyp. Polypectomy was then performed to make a diagnosis. Primary rectal teratoma also should be distinguish from local spread of teratomas arising in adjacent organs, which can be caused by spontaneous rupture or fistula formation [9,14]. Imaging studies are useful to visualize structures adjacent to the tumor [20,21].

Histologically, teratomas are classified as mature cystic or solid (benign), immature (malignant), or monodermal (eg, struma ovarii, carcinoid tumor) [1]. Mature cystic teratomas differentiate mainly along ectodermal lines to create a squamous-lined cyst that is filled with hair, sebaceous material, and teeth [20]. Ectodermal elements include the epidermis, skin appendage, and brain tissue. Monodermal tissue is represented by bone, cartilage, fat, and smooth muscle. Endodermal derivatives, such as the respiratory epithelium, gastrointestinal epithelium, and thyroid tissue, can be found. Mature solid teratomas probably have the same histogenetic origin as cystic teratomas, but they lack predominant differentiation into ectodermal tissue to form a squamous-lined cyst [20]. Solid regions raise concern for malignancy. Areas of necrosis in a solid tumor are consistent with immature teratomas but should not be found in mature solid teratomas [21]. Immature teratomas tend to be solid and contain areas that vaguely resemble normal tissues and small cysts. Microscopically, these tumors contain mature elements admixed with variable amounts of immature elements [21]. Histologic grading is based on the amount of immature neuroepithelium identified. Therefore, rigorous sampling and careful histological examination are recommended to exclude immature elements in tumors with large solid components [21]. Malignant transformation can occur in 1% to 2% of mature cystic teratomas, and squamous cell carcinoma accounts for 80% of these cases [20,21]. In fact, no case of malignancy arising in a primary rectal teratoma has been reported [2]. However, identification of associated malignancies with adequate sectioning is important for management and prognosis.

Complete resection is optimal because most primary rectal teratomas are benign, and no reports exist of recurrence of primary rectal teratoma after curative resection [2,3,14]. Considering the occurrence of complications, such as rupture, bleeding, and malignant changes in gonadal teratomas, it is reasonable to remove rectal teratomas [2]. Endoscopic resection is indicated for a pedunculated polyp that measures <4 cm. If the diagnosis is unclear or malignancy cannot be excluded, surgical resection is preferable [3,17,22]. Occasionally, teratomas arising in the ovary or the presacral area extend to the rectal wall; that should be ruled out before surgery [9,22]. Because our patient’s lesion was a pedunculated polyp measuring approximately 4 cm, endoscopic resection was performed to make a diagnosis.

Our case report has a limitation. Because the pedunculated polyp was successfully removed by endoscopy and it was diagnosed as a primary rectal teratoma, the patient did not undergo imaging at the time of diagnosis. In addition, she had no signs or symptoms after resection. However, imaging studies would be important to confirm that there are no other masses because the prognosis depends on timely resection [2,14,20]. Therefore, our patient will undergo an abdominal CT during a follow-up visit.

Conclusions

Primary rectal teratomas are extremely rare. However, when polypoid lesions are found in the rectum, teratoma should be considered in the differential diagnosis. Using clinical findings and histologic examination, primary rectal teratomas should be distinguished from local spread of teratomas arising in adjacent organs as well as from other neoplastic polyps. Primary rectal teratomas are usually mature (benign) but can undergo malignant transformation. Therefore, complete resection of a rectal teratoma is recommended to ameliorate symptoms and avoid the risk of malignancy.