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Literature DB >> 33518159

Precision Medicine and Obesity.

Maria Daniela Hurtado A¹, Andres Acosta².

Abstract

The highly variable response to obesity therapies justifies the search for treatment strategies that are best suited to individual patients to enhance their effectiveness and tolerability via precision medicine. Precision medicine development in recent years has been driven by the emergence of powerful methods to characterize patients ("omic" assays). Current available information has revealed that there are numerous intermediary processes that contribute to obesity and have provided a framework for partially comprehending the mechanisms behind the heterogeneity of obesity and its clinical consequences. Some of these processes have or are currently being targeted to individualize obesity therapy with some success.

Entities: Chemical

Keywords: Nutrigenomics; Obesity; Personalized nutrition; Phenotype; Precision medicine

Mesh：

Year: 2021 PMID： 33518159 PMCID： PMC7863578 DOI： 10.1016/j.gtc.2020.10.005

Source DB: PubMed Journal: Gastroenterol Clin North Am ISSN： 0889-8553 Impact factor: 3.806

62 in total

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Journal: J Nutrigenet Nutrigenomics Date: 2011-05-28

2. A new initiative on precision medicine.

Authors: Francis S Collins; Harold Varmus
Journal: N Engl J Med Date: 2015-01-30 Impact factor: 91.245

Review 3. A systematic review of genetic syndromes with obesity.

Authors: Y Kaur; R J de Souza; W T Gibson; D Meyre
Journal: Obes Rev Date: 2017-03-27 Impact factor: 9.213

4. The body-mass index of twins who have been reared apart.

Authors: A J Stunkard; J R Harris; N L Pedersen; G E McClearn
Journal: N Engl J Med Date: 1990-05-24 Impact factor: 91.245

Review 5. Insights into the role of the microbiome in obesity and type 2 diabetes.

Authors: Annick V Hartstra; Kristien E C Bouter; Fredrik Bäckhed; Max Nieuwdorp
Journal: Diabetes Care Date: 2015-01 Impact factor: 19.112

6. Polymorphisms of the GR and HSD11B1 genes influence body mass index and weight gain during hormone replacement treatment in patients with Addison's disease.

Authors: Ágnes Molnár; Annamária Kövesdi; Nikolette Szücs; Miklós Tóth; Péter Igaz; Károly Rácz; Attila Patócs
Journal: Clin Endocrinol (Oxf) Date: 2016-02-18 Impact factor: 3.478

7. Twin study of genetic and environmental influences on adult body size, shape, and composition.

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Journal: Int J Obes Relat Metab Disord Date: 2004-01

8. Gut microbiota from twins discordant for obesity modulate metabolism in mice.

Authors: Vanessa K Ridaura; Jeremiah J Faith; Federico E Rey; Jiye Cheng; Alexis E Duncan; Andrew L Kau; Nicholas W Griffin; Vincent Lombard; Bernard Henrissat; James R Bain; Michael J Muehlbauer; Olga Ilkayeva; Clay F Semenkovich; Katsuhiko Funai; David K Hayashi; Barbara J Lyle; Margaret C Martini; Luke K Ursell; Jose C Clemente; William Van Treuren; William A Walters; Rob Knight; Christopher B Newgard; Andrew C Heath; Jeffrey I Gordon
Journal: Science Date: 2013-09-06 Impact factor: 47.728

9. Amino Acid Signatures to Evaluate the Beneficial Effects of Weight Loss.

Authors: Nina Geidenstam; Martin Magnusson; Anders P H Danielsson; Robert E Gerszten; Thomas J Wang; Lovisa E Reinius; Hindrik Mulder; Olle Melander; Martin Ridderstråle
Journal: Int J Endocrinol Date: 2017-04-16 Impact factor: 3.257

10. Gut microbiome of the Hadza hunter-gatherers.

Authors: Stephanie L Schnorr; Marco Candela; Simone Rampelli; Manuela Centanni; Clarissa Consolandi; Giulia Basaglia; Silvia Turroni; Elena Biagi; Clelia Peano; Marco Severgnini; Jessica Fiori; Roberto Gotti; Gianluca De Bellis; Donata Luiselli; Patrizia Brigidi; Audax Mabulla; Frank Marlowe; Amanda G Henry; Alyssa N Crittenden
Journal: Nat Commun Date: 2014-04-15 Impact factor: 14.919

2 in total

Review 1. Precision Medicine and Obesity.

Authors: Daniel Sacoto; Maria Daniela Hurtado; Andres Acosta
Journal: Handb Exp Pharmacol Date: 2022

2. RNA modification-related variants in genomic loci associated with body mass index.

Authors: Jingyun Wu; Mimi Wang; Limin Han; Huan Zhang; Shufeng Lei; Yonghong Zhang; Xingbo Mo
Journal: Hum Genomics Date: 2022-07-25 Impact factor: 6.481

2 in total