| Literature DB >> 33516594 |
Susana K Checa1, Germán F Giri2, Martín Espariz2, José M Argüello3, Fernando C Soncini4.
Abstract
Copper (Cu) plays a key role at the host-pathogen interface as both an essential element and a toxic element. Intracellular strains of pathogenic Salmonella have acquired the periplasmic Cu chaperone, CueP, and the thiol oxidoreductases complex Scs, while losing the ancestral Cu-detoxification Cus system. Coregulation of these species-specific factors link Cu with redox stress and allows Salmonella to counteract Cu toxicity during infection.Entities:
Keywords: CueP and Cus; bacterial envelope; copper; enteropathogens; host–pathogen interaction
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Year: 2021 PMID： 33516594 PMCID： PMC9185223 DOI： 10.1016/j.tim.2021.01.004
Source DB: PubMed Journal: Trends Microbiol ISSN： 0966-842X Impact factor: 18.230