| Literature DB >> 33516265 |
Jing Kong1,2,3, Shiyuan Wen1,4, Wenjing Cao1,2, Peng Yue1,2, Xin Xu1,4, Yu Zhang1,4, Lisha Luo1,2, Taigui Chen1,4, Lianbao Li1,4, Feng Wang1,4, Jian Tao3, Guozhong Zhou1,4, Suyi Luo1,4, Aihua Liu5,6,7, Fukai Bao8,9,10.
Abstract
Organoids are derived from stem cells or organ-specific progenitors. They display structures and functions consistent with organs in vivo. Multiple types of organoids, including lung organoids, can be generated. Organoids are applied widely in development, disease modelling, regenerative medicine, and other multiple aspects. Various human pulmonary diseases caused by several factors can be induced and lead to different degrees of lung epithelial injury. Epithelial repair involves the participation of multiple cells and signalling pathways. Lung organoids provide an excellent platform to model injury to and repair of lungs. Here, we review the recent methods of cultivating lung organoids, applications of lung organoids in epithelial repair after injury, and understanding the mechanisms of epithelial repair investigated using lung organoids. By using lung organoids, we can discover the regulatory mechanisms related to the repair of lung epithelia. This strategy could provide new insights for more effective management of lung diseases and the development of new drugs.Entities:
Keywords: Epithelial repair; Lung injury; Lung organoid; Stem cell
Mesh：
Year: 2021 PMID： 33516265 PMCID： PMC7846910 DOI： 10.1186/s13287-021-02172-5
Source DB: PubMed Journal: Stem Cell Res Ther ISSN： 1757-6512 Impact factor: 6.832