| Literature DB >> 33515607 |
Carmen Schiweck1, Gara Arteaga-Henriquez2, Mareike Aichholzer3, Sharmili Edwin Thanarajah4, Sebastian Vargas-Cáceres5, Silke Matura3, Oliver Grimm3, Jan Haavik6, Sarah Kittel-Schneider7, Josep Antoni Ramos-Quiroga2, Stephen V Faraone8, Andreas Reif3.
Abstract
Attention-deficit / hyperactivity disorder (ADHD) and Bipolar Disorder (BD) are common mental disorders with a high degree of comorbidity. However, no systematic review with meta-analysis has aimed to quantify the degree of comorbidity between both disorders. To this end we performed a systematic search of the literature in October 2020. In a meta-analysis of 71 studies with 646,766 participants from 18 countries, it was found that about one in thirteen adults with ADHD was also diagnosed with BD (7.95 %; 95 % CI: 5.31-11.06), and nearly one in six adults with BD had ADHD (17.11 %; 95 % CI: 13.05-21.59 %). Substantial heterogeneity of comorbidity rates was present, highlighting the importance of contextual factors: Heterogeneity could partially be explained by diagnostic system, sample size and geographical location. Age of BD onset occurred earlier in patients with comorbid ADHD (3.96 years; 95 % CI: 2.65-5.26, p < 0.001). Cultural and methodological differences deserve attention for evaluating diagnostic criteria and clinicians should be aware of the high comorbidity rates to prevent misdiagnosis and provide optimal care for both disorders.Entities:
Keywords: ADHD; Adult bipolar disorder; Age of onset; Attention deficit hyperactivity disorder; Comorbidity; Prevalence
Mesh：
Year: 2021 PMID： 33515607 DOI： 10.1016/j.neubiorev.2021.01.017
Source DB: PubMed Journal: Neurosci Biobehav Rev ISSN： 0149-7634 Impact factor: 8.989